Results 191 to 200 of about 20,373,278 (386)

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Letters to the Editor [PDF]

, 2004
Catholic Medical Association
core   +1 more source

The Future of Rural Medical Education in Australia. [PDF]

Aust J Rural Health
Padley J.
europepmc   +1 more source

MEDICAL PIONEER, AERONAUTS [PDF]

, 1919
F. J. Poynton
openalex   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

[Book Review of] \u3cem\u3eGeorge Pell\u3c/em\u3e, by Tess Livingstone [PDF]

, 2005
Catholic Medical Association
core   +1 more source

A Transition Course to Reverse Empathy Decline in Medical Students. [PDF]

Clin Teach
Howick J, Slavin D, Bennett-Weston A, Eyres C, Ward A, Keshtkar L, Parkinson S, Williams C, Solomon-Taylor J.   +8 more
europepmc   +1 more source

THE DIFFERENTIAL DIAGNOSIS OF SYPHILIS AND PARASYPHILIS OF THE NERVOUS SYSTEM: Introduction to a Discussion on Syphilis and Parasyphilis of the Nervous System at the Medical Society of London on November 13th, 1911 [PDF]

, 1911
F. W. Mott
openalex   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

Medical Mission Sisters Report 1943 Attendance Largest in History of Mission Hospital [PDF]

, 1944
Medical Mission Sisters
core   +1 more source