Results 171 to 180 of about 16,514,941 (283)
Club Activity, Study Groups, and Academic Achievement: A Nationwide Study of Japanese Medical Students' Extracurricular Life. [PDF]
J Gen Fam MedFujikawa H, Tamune H, Nishizaki Y, Mori H, Fukui S, Shikino K, Shimizu T, Yamamoto Y, Kobayashi H, Naito T, Tokuda Y. +10 moreeuropepmc +1 more sourcePre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan +11 morewiley +1 more sourceDifferent SARS-CoV-2 Subvariants and Coagulation Markers Trend: A Retrospective Multicentric Study From Iranian Network for Research in Viral Diseases (INRVD). [PDF]
Health Sci RepRazavi A, Koltapeh MP, Nazari T, Morvaridi A, Banivaheb B, Saeb S, Moulaeian M, Zakaryaei A, Sabzalian A, Raei M, Razavi B, Motlaghzadeh S, Hosseini SS, Karami H, Ghafari P, Aboofazeli A, Nastarvand S, Sarabi NKN, Avakian A, Ebadinejad S, Keyhani T, Danafar P, Rahimlou R, Heidarian S, Mondeali M, Nafe-Monfared F, Jafarpour M, Samiee M, Birang F, Mirzazadeh A, Abadi SAF, Barkhordari K, Siavoshi S, Biklari M, Khodabakhsh M, Javadi A, Mirzaee S, Didgar F, Etebari M, Soltanmohamad S, Shahbaz B, Kord E, Shahri SMH, Ebrahimzade M, Moghaddam AA, Sanavi FS, Moattari A, Edalat F, Sheijani MF, Moghadami M, Yaghubi T, Mojtahedi A, Heidarzadeh A, Naghipour M, Luyeh MS, Nazemi P, Alipasandi K, Albaji M, Afzali M, Shokouhi N, Ezani A, Najari HR, Hosseini M, Ghobadi A, Momeni A, Fattahi SZ, Mohsenzadeh M, Jafari M, Azizi A, Pouryousef S, Tabarraei A, Moradi A, Azimi S, Yahyapour Y, Bayani M, Poortahmasebi V, Varshochi M, Ziaee M, Ghafari S, Javanmard D, Soleimani A, Mozhgani SH, Mokhames Z, Akhoundimeybodi Z, Astani A, Abdollahi A, Hadadi A, Salehi MR, Hajiabdolbaghi M, Raeeskarami SR, Kafan S, Montazeri M, Pazoki M, Riahi T, Talebi-Taher M, Ataei-Pirkooh A, Bokharaei-Salim F, Faiz SHR, Kalantari S, Yasin Z, Jazayeri SM. +100 moreeuropepmc +1 more sourceEDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot +36 morewiley +1 more sourceEngineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang +12 morewiley +1 more sourceInterrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne +61 morewiley +1 more source
