Results 191 to 200 of about 13,541,940 (307)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

AI in UK Medical Education: A Framework for Curriculum Reform. [PDF]

JMIR Med Educ
Gaur A, Kirani Tan J, Sridhar Rao M, Fuad M, Bhatti T, Rishab Bharadwaj H, Mohamed Ahmed KAH.   +6 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

THE MEDICAL LIBRARY AND THE MEDICAL STUDENT.

Bulletin of the Medical Library Association, 1996
E C, Long, P G, Miller
openaire   +3 more sources

Author Correction: PCM1 orchestrates centrosomal and flagellar protein transport to promote sperm maturation. [PDF]

Commun Biol
Huang Z, Yi R, Cen X, Zhang H, Xie M, Ma K, Ruan S, Zhuang Y, Zhang X, Liu W, Feng H, Chen D, Ahmed MMM, Liu H, Huang C, Kang X, Chen Z.   +16 more
europepmc   +1 more source

Southwest view of Medical College quadrangle

This glass lantern slide features a ground view of the southwest side of the Medical College of South Carolina ...
Medical College of South Carolina (1952-1969). Department of Medical Illustration
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Process assessment of the attitude, ethics, and communication (AETCOM) sessions: student engagement and satisfaction among medical students in central India. [PDF]

BMC Med Educ
Dhaneria M, Shrivastava S, Shaiva R, Golecha A, Pathak A.   +4 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Human-in-the-Loop as a Safety Guardrail: Clinical Accountability in the Large Language Model Era. [PDF]

J Med Internet Res
Zablah I, Molina Y, Garcia-Loureiro A.
europepmc   +1 more source