Results 141 to 150 of about 2,779,055 (335)

Integrative analysis of circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients: a comprehensive approach

Molecular Oncology, EarlyView.
This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou, Argyro Roumeliotou, Evangelia Pantazaka, Athanasios‐Nasir Shaukat, Athina Christopoulou, Angelos Koutras, Foteinos‐Ioannis Dimitrakopoulos, Vassilis Georgoulias, Anastasia Xagara, Evangelia Chantzara, Fillipos Koinis, Athanasios Kotsakis, Constantinos Stathopoulos, Galatea Kallergi   +13 more
wiley   +1 more source

Euthanizing people who are 'tired of life' [PDF]

, 2017
In Belgium and the Netherlands, a debate is developing about people who express a desire to end their lives although they do not suffer from an incurable, life-threatening disease.
Cohen-Almagor, Raphael
core   +1 more source

The accumulation of myeloid‐derived suppressor cells participates in abdominal infection‐induced tumor progression through the PD‐L1/PD‐1 axis

Molecular Oncology, EarlyView.
This study explores how sepsis affects GC progression by creating an immunosuppressive environment. Our findings reveal that sepsis promotes immune dysregulation, enhancing tumor growth and metastasis. Targeting the PD‐1/PD‐L1 pathway with monoclonal antibodies shows potential for restoring immune function and improving outcomes in cancer patients ...
Yiding Wang, Ting Guo, Xiaofang Xing, Xijuan Liu, Xuejun Gan, Yingai Li, Yan Liu, Fei Shan, Zhouqiao Wu, Jiafu Ji, Ziyu Li   +10 more
wiley   +1 more source

An argument for physician-assisted suicide and against euthanasia [PDF]

, 2015
The article opens with the hypothesis that the default position that should guide healthcare providers when treating patients at the end-of-life is that patients opt for life. In the absence of an explicit request to die, we may assume that patients wish
Beckford, Bedell, Bernheim, Bilsen, Bilsen, Casarett, Chambaere, Chambaere, Chamber of the Representatives of Belgium, Cohen-Almagor, Cohen-Almagor, Cohen-Almagor, Cohen-Almagor, Cohen-Almagor, Cohen-Almagor, Cohen-Almagor, Cohen-Almagor, Cohen-Almagor, Cook, Cook, Cook, Cook, Culzac, de Diesbach, Delamothe, Deliens, den Hartogh, Gamondi, General Medical Council, Gomez, Haerens, Hardwig, Harris, Hendin, Heneghan, Jochemsen, Keown, Keown, Kuhse, Kuhse, Kuhse, Onwuteaka-Philipsen, Onwuteaka-Philipsen, Pardon, Quebec Bill 52, Schuklenk, Sercu, Sheldon, Singer, Sprung, Steck, Swildens-Rozendaal, van der Heide, van der Heide, van der Heide, van der Wal, Visser   +56 more
core   +1 more source

Using movies to teach professionalism to medical students

BMC Medical Education, 2011
Background Professionalism topics are usually not covered as a separate lesson within formal curriculum, but in subtler and less officially recognized educational activities, which makes them difficult to teach and assess.
Klemenc-Ketis Zalika, Kersnik Janko
doaj   +1 more source

Medical aid in dying: A foreseen decisive role for the specialized nurse practitioner in Quebec

, 2022
Paweł Król, Emmanuelle Hudon, Olivier Paquet   +2 more
openalex   +2 more sources

Polyfunctional CD8+CD226+RUNX2hi effector T cells are diminished in advanced stages of chronic lymphocytic leukemia

Molecular Oncology, EarlyView.
CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar, Shima Shahbaz, Anthea C. Peters, Spencer B. Gibson, Shokrollah Elahi   +4 more
wiley   +1 more source

Medical students writing on death, dying and palliative care : a qualitative analysis of reflective essays [PDF]

, 2016
Background: Medical students and doctors are becoming better prepared to care for patients with palliative care needs and support patients at the end of life. This preparation needs to start at medical school.
Boland, Jason W, Boland, Jason W., Dikomitis, Lisa, Gadoud, Amy   +3 more
core   +3 more sources

Unmet needs of patients with cancer in their last year of life as described by caregivers in a developing world setting: a qualitative study

BMC Palliative Care, 2020
Background Palliative care is in its infancy in most of the developing world. We set out to explore the lived experiences of families and caregivers of recently deceased cancer patients in Trinidad and Tobago and to determine the unmet needs of the ...
Karen Cox-Seignoret, Rohan G. Maharaj
doaj   +1 more source

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

Molecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, Michelle Karam, Christian Potts, Princess Rodriguez, Ya‐Wei Qiang, Habib Hamidi, Xiangnan Guan, Calvin P. H. Vary, Michaela R. Reagan   +12 more
wiley   +1 more source