Results 121 to 130 of about 120,136,022 (282)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

French psychiatrists’ perspectives on proposed medical aid in dying legislation

International audienceIntroduction: France is poised to legalize Medical Aid in Dying (MAiD). Such a law may have potential implications for mental healthcare.Methods: We conducted an anonymous survey of 168 French psychiatrists between June and July ...
Olie, Emilie, Courtet, Philippe
core   +1 more source

From disavowal to dialogue: forging collaborative ethical, clinical, and medical approaches to severe and enduring anorexia nervosa

Journal of Eating Disorders
Anorexia nervosa carries one of the highest mortality rates among psychiatric disorders, yet care pathways for individuals with longstanding, treatment-resistant illness continue to pose significant challenges.
Maryrose Bauschka, Anne Marie O’Melia
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

EXPERTS WEIGH IN: EXAMINING THE DEBATE ABOUT MEDICAL ASSISTANCE IN DYING (MAID) FOR MENTAL ILLNESS IN CANADA

, 2023
The prospect of implementing Medical Assistance in Dying (MAiD) for persons with mental illness as their sole underlying medical condition (MI-SUMC) has generated a polarizing discussion among experts, whose discourses influence public opinion and policy
Kanigan-Taylor, Sydney
core  

The night is dark and full of hesitation. The latest step in the legal trajectory of assisted suicide in Italy: through tentative judicial openings, bioethical contradictions and the Parliament’s deafness

Frontiers in Pharmacology
The legalization of voluntary assisted dying, or physician-assisted suicide (AS), is gaining momentum as the recognition of a patient’s right to self-determination becomes increasingly integral to medical practice, even in cases involving extreme ...
Paola Frati, Marco Albore, Eleonora Micaela Ertola, Sossio Del Prete, Letizia Sorace, Raffaele La Russa, Giorgio Bolino   +6 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

“Can’t you at least die with a little dignity?” The Right to Die Debates and Normative Dignity

BioéthiqueOnline, 2014
In recent decades, the right to die has emerged as one of the most divisive social and political questions in North America and Europe, one that involves the mobilization of numerous social actors and activists as well as several legal challenges. In Qué
Gandsman, Ari, Burnier, Daniel
doaj