Results 101 to 110 of about 120,136,022 (282)
Union Medical Association Papers (1758 – 1858): A Finding Aid [PDF]
, 2017 The Union Medical Association papers are fully digitized. This collection was processed by Dina Litvak in 2015. The finding aid was last reviewed and updated by Kristine Sjostedt in July 2016.The Union Medical Association was officially established at ...
Sjostedt, Kristine M., Litvak, Dina
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Considering Medical Aid in Dying
On Wednesday, May 1, 2024, the Consortium on Law and Values hosted the first installment of the "When Law, Ethics & Medicine Collide" Lecture Series. "Considering Medical Aid in Dying" was moderated by Susan M.
Consortium on Law and Values in Health, Environment, & the Life Sciences
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Death and Dignity: Approaches to Medical Aid-in-Dying and Recommendations for Nevada
, 2022 Advancements in medicine, surgery, and treatment have prolonged life spans in a way that presents new considerations for death and dying. When it comes to terminal illnesses, all of these innovations increase life expectancy but cannot do the same for a ...
Winchell, Cecilia
core
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Legal Implications of Psychiatric Assessment for Medical Aid in Dying. [PDF]
In recent years, several jurisdictions have passed legislation to permit medical aid in dying (MAID) worldwide, with considerable expansion in the availability of this practice.
Binder, Renée L +3 more
core +1 more source
Why reflexivity matters in the literature of suffering, death, and dying in eating disorders
Journal of Eating DisordersCurrent debates on medical aid in dying and treatment futility in longstanding eating disorders emphasize diagnostic frameworks, ethical principles, and legal statutes.
Scout Silverstein
doaj +1 more source
Transplant InternationalOrgan Donation after Euthanasia starting at Home (ODEH) initiates the euthanasia trajectory at home with deep sedation, followed by transfer to the hospital for completion of euthanasia and organ procurement.
Isabelle Manders +8 more
doaj +1 more source