Results 81 to 90 of about 31,257 (277)

Voluntarily stopping eating and drinking (VSED) to hasten death: may clinicians legally support patients to VSED?

BMC Medicine, 2017
Jox and colleagues recently compared and contrasted two leading end-of-life exit options, namely voluntarily stopping eating and drinking (VSED) and medical aid in dying (MAID).
Thaddeus Mason Pope
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Medical Aid in dying in Quebec - legal considerations

, 2014
Currently, Quebec is the only province in Canada, which has taken a decision on legalizing euthanasia and physician assisted suicide. In Quebec euthanasia and physician assisted suicide are labelled as medical aid in dying and perceived as a part of ...
Slokenberga, Santa,, Zillén, Kavot,
core  

Requests for physician-assisted suicide in German general practice: frequency, content, and motives– a qualitative analysis of GPs’ experiences

BMC Primary Care
Background Physician-assisted suicide (PAS) has been legalised in an increasing number of countries in Western Europe. In Germany, after a landmark decision by the Federal Constitutional Court in 2020, the ban on PAS was removed from the Model Medical ...
Luise Farr, Juliane Poeck, Claudia Bozzaro, Jutta Bleidorn   +3 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Medical Aid in Dying: Challenges and Solutions

, 2022
Medical aid in dying (MAID) is currently legal in ten US states and the District of Columbia. The most frequent reasons for requesting MAID are typically loss of autonomy, decreasing ability to participate in pleasurable activities, impaired quality of ...
Walker, Hilary, Kinney, Judy, Vandekieft, Gregg, Morris, Barbara, Chandran, Devyani   +4 more
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Physician and Nurse Practitioner Attitudes on Medical Aid in Dying in Long Term Care Settings: A Qualitative Study

Medical Aid in Dying (MAiD) was decriminalized in Canada with the implementation of Bill C-14 in February of 2016. In the ensuing months and years, a number of discussions and court challenges have clarified the approach to Medical Aid in Dying, and has
Craig Mara
core   +1 more source

Scripting death ::stories of assisted dying in America /

, 2021
"How the legalization of assisted dying is changing our lives. Over the past five years, medical aid-in-dying (also known as assisted suicide) has expanded rapidly in the United States, and is now legally available to one in five Americans.
Buchbinder, Mara,
core   +1 more source