Results 91 to 100 of about 31,257 (277)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Exploring the interplay of clinical, ethical and societal dynamics: two decades of Medical Assistance in Dying (MAID) on psychiatric grounds in the Netherlands and Belgium

Frontiers in Psychiatry
This paper explores recently emerging challenges in Medical Assistance in Dying on Psychiatric Grounds (MAID-PG), focusing on ethical, clinical, and societal perspectives. Two themes are explored. First, the growing number of young MAID-PG requestors and
Monica Verhofstadt, Radboud Marijnissen, Daan Creemers, Daan Creemers, Sanne Rasing, Sanne Rasing, Lizanne Schweren, Sigrid Sterckx, Koen Titeca, Sisco van Veen, Rosalie Pronk   +10 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Embracing the End: A Comparative Analysis of Medical Aid in Dying in Canada and the United States

, 2022
Since the late nineteenth century, debate has unfolded over the use of euthanasia and physician-assisted death to alleviate the suffering of individuals with medical illnesses.
Krinsky, Joel
core   +2 more sources

Medical acts at the end of life and death

Revista de Direito Sanitário
Aid at the end of life and dying includes the use of therapeutic methods or procedures such as palliative care, euthanasia, and assisted suicide. The recognition of these procedures as medical acts is a major point of debate.
Carlos Jesús Molina-Ricaurte
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Who joins a UK right to die society and why? : a study of members of Friends at the End (FATE)

, 2012
PhDThe thesis presents quantitative and qualitative thematic analyses of a postal survey and interview study of members of Friends at the End (FATE), a Glasgow-based right to die society.
Judd, Marion Buchanan
core  

Legal Implications of Psychiatric Assessment for Medical Aid in Dying. [PDF]

In recent years, several jurisdictions have passed legislation to permit medical aid in dying (MAID) worldwide, with considerable expansion in the availability of this practice.
Binder, Renée L, McNiel, Dale E, Hanif, Hira, Weithorn, Lois   +3 more
core   +1 more source

Managing Profound Suffering at the End-of-Life: Should expanding access to continuous deep sedation be the priority?

BioéthiqueOnline, 2015
This paper argues that in addressing and managing profound suffering at the end-of-life, the priority should not be the legalization of physician-assisted suicide or voluntary active euthanasia in jurisdictions where these practices are not currently ...
Kirby, Jeffrey
doaj  

Assisted Suicide Heads to Colorado

Voices in Bioethics, 2017
While the outcome of our recent election cycle has represented a country with polarized viewpoints of America’s future policies, one ballot initiative has emerged as a force of consensus.
Tyler Cosmer
doaj   +1 more source