Results 71 to 80 of about 241,964 (292)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

How to talk with dying patients and their families after disasters and humanitarian crises: a review of available tools and guides for disaster responders

Journal of International Humanitarian Action, 2019
In responding to those affected by sudden onset disasters and chronic humanitarian crises, disaster responders and humanitarian aid workers will face the challenge of caring for dying patients.
B. R. Daubman, H. Cranmer, L. Black, A. Goodman   +3 more
doaj   +1 more source

The Constitutional Right to Die: Ethical Considerations [PDF]

, 1997
In this commentary, the author first looks at some ethical reasoning supporting physician-assisted dying. Second, he examines some of the lines that have been drawn between withdrawing and withholding life-sustaining treatment on the one hand, and ...
Gostin, Lawrence O.
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Voluntarily stopping eating and drinking (VSED) to hasten death: may clinicians legally support patients to VSED?

BMC Medicine, 2017
Jox and colleagues recently compared and contrasted two leading end-of-life exit options, namely voluntarily stopping eating and drinking (VSED) and medical aid in dying (MAID).
Thaddeus Mason Pope
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Requests for physician-assisted suicide in German general practice: frequency, content, and motives– a qualitative analysis of GPs’ experiences

BMC Primary Care
Background Physician-assisted suicide (PAS) has been legalised in an increasing number of countries in Western Europe. In Germany, after a landmark decision by the Federal Constitutional Court in 2020, the ban on PAS was removed from the Model Medical ...
Luise Farr, Juliane Poeck, Claudia Bozzaro, Jutta Bleidorn   +3 more
doaj   +1 more source

The Right to a Good Death: Bridging an Ethical Divide Between Veterinary Euthanasia and Medical Aid in Dying

Journal of Animal Law, Ethics and One Health
Does the ethical reasoning we extend to the animals we love offer a foundation for recognizing a human right to a dignified death? This paper argues that it does.
Bryan E. Roberts
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

How the mass media report social statistics: A case study concerning research on end-of-life decisions [PDF]

, 2010
This is the post-print version of the final paper published in Social Science & Medicine. The published article is available from the link below. Changes resulting from the publishing process, such as peer review, editing, corrections, structural ...
Bauman, Bell, Best, Best, Best, Boyce, Cicourel, Clive Seale, Deacon, Entwistle, Fenton, Fenton, Galtung, Gorer, Harcup, Hausmann, Jackson, Kitzinger, Kitzinger, Kuhse, Langer, Lewis, McInerney, McInerney, McInerney, Mellor, Nelkin, Osborne, Pollock, Rietjens, Schmierbach, Seale, Seale, Seale, Seale, Seale, Seale, Seale, Signorielli, Sparks, Sykes, van der Heide, van der Maas, Wakefield, Williams   +44 more
core   +1 more source