Results 71 to 80 of about 116,264,275 (283)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Dying in hospital: medical failure or natural outcomes?

, 2001
The purpose of this study was to describe patterns of medical and nursing practice in the care of patients dying of oncological and hematological malignancies in the acute care setting in Australia.
Middlewood, Sue, Gardner, Glenn, Gardner, Glenn E., Gardner, Anne   +3 more
core   +1 more source

The euthanasia law from the perspective of healthcare professionals in Spain

BMC Medical Ethics
Background In 2021, Spain passed Organic Law 3/2021, which regulates euthanasia and represents an extension of rights to make decisions in the context of health care.
Rosana Triviño-Caballero, Mª Teresa López de la Vieja, Isabel Roldán-Gómez, Mª Isabel Tamayo-Vázquez, Tayra Velasco-Sanz   +4 more
doaj   +1 more source

Aftercare Provision for Bereaved Relatives Following Euthanasia or Physician-Assisted Suicide: A Cross-Sectional Questionnaire Study Among Physicians

International Journal of Public Health
Objectives: Relatives of patients who died after euthanasia or physician-assisted suicide (EAS) might need (specific) aftercare. We examined if and how physicians provide aftercare to bereaved relatives of patients who died after EAS, and which patient-,
Sophie C. Renckens, Sophie C. Renckens, H. Roeline Pasman, H. Roeline Pasman, Agnes van der Heide, Bregje D. Onwuteaka-Philipsen, Bregje D. Onwuteaka-Philipsen   +6 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Medical Aid in dying in Quebec - legal considerations

, 2014
Currently, Quebec is the only province in Canada, which has taken a decision on legalizing euthanasia and physician assisted suicide. In Quebec euthanasia and physician assisted suicide are labelled as medical aid in dying and perceived as a part of ...
Slokenberga, Santa,, Zillén, Kavot,
core  

EXPERTS WEIGH IN: EXAMINING THE DEBATE ABOUT MEDICAL ASSISTANCE IN DYING (MAID) FOR MENTAL ILLNESS IN CANADA

, 2023
The prospect of implementing Medical Assistance in Dying (MAiD) for persons with mental illness as their sole underlying medical condition (MI-SUMC) has generated a polarizing discussion among experts, whose discourses influence public opinion and policy
Kanigan-Taylor, Sydney
core  

How to talk with dying patients and their families after disasters and humanitarian crises: a review of available tools and guides for disaster responders

Journal of International Humanitarian Action, 2019
In responding to those affected by sudden onset disasters and chronic humanitarian crises, disaster responders and humanitarian aid workers will face the challenge of caring for dying patients.
B. R. Daubman, H. Cranmer, L. Black, A. Goodman   +3 more
doaj   +1 more source