Results 111 to 120 of about 116,264,275 (283)

Factors That Influence Access to Medical Assistance in Dying Services: An Integrative Review

Background In nearly all jurisdictions where it is permitted, Medical Assistance in Dying is situated in a healthcare system. Currently, limited evidence demonstrates how supply and demand factors influence access to Medical Assistance in Dying ...
Hewitt, Jayne, Bonner, Ann, Wilson, Michael, Bloomer, Melissa   +3 more
core   +1 more source

Medical Aid in Dying Education for Hospice Nurses [PDF]

Background: Medical aid in dying (MAID) is an option surrounding end-of-life care for hospice patients. This process gives patients the autonomy to end their life during the time and location of their choosing.
Woo, Ian K
core   +3 more sources

Why reflexivity matters in the literature of suffering, death, and dying in eating disorders

Journal of Eating Disorders
Current debates on medical aid in dying and treatment futility in longstanding eating disorders emphasize diagnostic frameworks, ethical principles, and legal statutes.
Scout Silverstein
doaj   +1 more source

Organ donation after euthanasia starting at home: a mixed-methods study of preliminary nationwide Dutch experiences

Transplant International
Organ Donation after Euthanasia starting at Home (ODEH) initiates the euthanasia trajectory at home with deep sedation, followed by transfer to the hospital for completion of euthanasia and organ procurement.
Isabelle Manders, Nathalie van Dijk, Johan Sonneveld, Wim de Jongh, Jan Bollen, Nichon E. Jansen, Walther van Mook, Walther van Mook, Walther van Mook   +8 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Physician and Nurse Practitioner Attitudes on Medical Aid in Dying in Long Term Care Settings: A Qualitative Study

Medical Aid in Dying (MAiD) was decriminalized in Canada with the implementation of Bill C-14 in February of 2016. In the ensuing months and years, a number of discussions and court challenges have clarified the approach to Medical Aid in Dying, and has
Craig Mara
core   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Reasonable Expectations and the First Millennium Development Goal: How Much Can Aid Achieve? [PDF]

While a political consensus has emerged to increase aid flows to Sub-Saharan Africa, empirical studies of the effectiveness of aid in stimulating growth and reducing poverty have yet to yield conclusive results.
Carl-Johan Dalgaard, Lennart Erickson
core