Results 181 to 190 of about 4,436,605 (332)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Author Response to Letter to the Editor Regarding “Risk Assessment of Falls Among Older Adults Based on Probe Reaction Time During Water-Carrying Walking” [Response to Letter]

Clinical Interventions in Aging
Fan Liu,1,* Huan Yu,1,* Qing Xu,2,* Jianwei Gong,1 Ming Huo,3 Fei Huang1,3 1School of Health and Life Sciences, Binzhou Medical University, Yantai, People’s Republic of China; 2Yaitai Hospital, Binzhou Medical University, Yantai, People&
Liu F, Yu H, Xu Q, Gong J, Huo M, Huang F   +5 more
doaj  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Correction to: Assessment of Burnout Among Faculty Members at Mazandaran University of Medical Sciences and Its Association with Demographic Factors [PDF]

Journal of Mazandaran University of Medical Sciences
Aliye Zamani Kiasari1, Seyed Hamzeh Hosseini2, Nassim Ghahrani3, Siavash Moradi4, Seyedkhosro Ghasempouri5,6, Ehsan Abedini7. Atefe Zabihi Zazooli8, Fattane Amuei9 1Associate Professor, Department of Anesthesiology, Faculty of Medicine, Mazandaran ...
Aliye Zamani Kiasari, Seyed Hamzeh Hosseini, Nassim Ghahrani, Siavash Moradi, Seyedkhosro Ghasempouri, Ehsan Abedini, Atefe Zabihi Zazooli, Fattane Amuei   +7 more
doaj  

Rates and predictors of data and code sharing in the medical and health sciences: Protocol for a systematic review and individual participant data meta-analysis. [PDF]

F1000Res, 2021
Hamilton DG, Fraser H, Fidler F, McDonald S, Rowhani-Farid A, Hong K, Page MJ.   +6 more
europepmc   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Earthquake Preparedness in Teaching Hospitals: a cross-sectional study in Yazd/ Iran [PDF]

Earthquake Preparedness in Teaching Hospitals: a cross-sectional study in Yazd/ Iran Abedi Mahdieh1, khanjankhani Khatere 1, Kiani Mohammad Mehdi2*, Seyed Abdel Hossein Mousavi Rigi3, Salehi Marzieh4 1 .M.Sc, School of Public Health, Shahid Sadoughi ...
Abedi, Mahdieh, khanjankhani, Khatere, Kiani, Mohammad Mehdi, Mousavi Rigi, Seyed Abdol Hossein, Salehi, Marzieh   +4 more
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Understanding cost variation in medical and health sciences education: An institutional perspective. [PDF]

Health Policy Open
Osmani AR.
europepmc   +1 more source