Results 191 to 200 of about 4,436,605 (332)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Hepatitis B knowledge among nursing students at Jiblah University for medical and health sciences. [PDF]

BMC Public Health
Kaid Al-Mohani S, Alahdal A, Almohtdi A, Alkhtib M, Almzgagi W, Marzh M, Almzgagi H.   +6 more
europepmc   +1 more source

Which doctor? Combining vignettes and item response to measure doctor quality [PDF]

The authors develop a method in which vignettes-a battery of questions for hypothetical cases-are evaluated with item response theory to create a metric for doctor quality. The method allows a simultaneous estimation of quality and validation of the test
Das, Jishnu, Hammer, Jeffrey
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Mental health burden and service barriers among medical and health sciences students: prevalence and determinants from a cross-sectional analysis. [PDF]

Front Psychol
Hassan SM, Alqahtani NM, Alshahrani SM, Abuelnasr AM, Alhefzy AA, Al Assiri KW, Al Assiri BW, Alharthi OS, Alharbi MM.   +8 more
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Challenges in student assessment in medical and health sciences education in Northern Iraq. [PDF]

BMC Med Educ
Aziz S, Hameed M, Azeez S, Omer S, Ameen K, Abdullah T, Nada M.   +6 more
europepmc   +1 more source

Effective Factors on Oral Health-Promoting Behaviors among Elementary School Students Based on BASNEF Model [PDF]

Effective Factors on Oral Health-Promoting Behaviors among Elementary School Students Based on BASNEF Model Naseri Pour Takallo Zohreh1, Ahmadi Tabatabaei Seyed Vahid2, Zolala Farzaneh3, Mohseni Mohabbat4* 1.
Ahmadi Tabatabaei, Seyed Vahid, Mohseni, Mohabbat, Naseri Pour Takallo, Zohreh, Zolala, Farzaneh   +3 more
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Predicting Academic Performance Among Female Undergraduate Medical and Health Sciences Students Through Sociodemographic, Socioeconomic, and Nutritional Factors. [PDF]

Cureus
Hakro S, Soomro MN, Keerio F, Chandio SM, Hassan F.   +4 more
europepmc   +1 more source