Results 71 to 80 of about 4,210,891 (389)

Medical cannabis in the UK [PDF]

BMJ, 2018
Patients should not be criminalised for seeking benefits: Do patients have the right to medicate themselves, or should they be punished for doing so? Should their doctors work with them to decide on the best treatment, or does the government know best? These questions are at the heart of the current debate on the use of cannabis as medicine. In the
openaire   +2 more sources

Medical cannabis for children: Evidence and recommendations.

Paediatrics & child health
Interest in using cannabis products for a medical purpose in children under the age of 18 years is increasing. There are many medical cannabis products available that can include cannabidiol (CBD) or delta-9-tetrahydrocannabinol (THC), or both.
Lauren E Kelly, Michael J Rieder, Yaron Finkelstein   +2 more
semanticscholar   +1 more source

Exogenous application of stress-related signaling molecules affect growth and cannabinoid accumulation in medical cannabis (Cannabis sativa L.)

Frontiers in Plant Science, 2022
Medical cannabis (Cannabis sativa L.) is a source of bioactive phytochemicals with promising pharmacological and therapeutic applications. Enhancing the accumulation of valuable bioactive compounds is potentially a way of increasing the economic ...
J. Garrido, Saleta Rico, C. Corral, C. Sánchez, N. Vidal, Juan José Martínez-Quesada, C. Ferreiro-Vera   +6 more
semanticscholar   +1 more source

Evaluating the role of a galanin enhancer genotype on a range of metabolic, depressive and addictive phenotypes [PDF]

, 2014
Funded by •ERC. Grant Number: 284167 •NIH. Grant Number: 1RO1DK0921127-01 •NWO.
Day, Ian, Farrer, Lindsay A, Gelernter, Joel, Heron, Jon, Hickman, Matthew, Kranzler, Henry R, Lewis, Glyn, MacKenzie, Alasdair, Minica, Camelia, Munafò, Marcus, Richardson, Tom G, Tavare, Jeremy, Vink, Jacqueline M, Wynick, David   +13 more
core   +2 more sources

Medical cannabis or cannabinoids for chronic pain: a clinical practice guideline

British medical journal, 2021
Clinical question What is the role of medical cannabis or cannabinoids for people living with chronic pain due to cancer or non-cancer causes? Current practice Chronic pain is common and distressing and associated with considerable socioeconomic burden ...
J. Busse, Patrick Vankrunkelsven, L. Zeng, A. Heen, A. Merglen, F. Campbell, Lars Petter, B. Aertgeerts, R. Buchbinder, M. Coen, D. Juurlink, C. Samer, R. Siemieniuk, Nimisha Kumar, L. Cooper, John Brown, L. Lytvyn, D. Zeraatkar, Li Wang, G. Guyatt, P. Vandvik, T. Agoritsas   +21 more
semanticscholar   +1 more source

Canadians’ use of cannabis for therapeutic purposes since legalization of recreational cannabis: a cross-sectional analysis by medical authorization status

BMC Medicine
Background There has been a precipitous decline in authorizations for medical cannabis since non-medical cannabis was legalized in Canada in 2018. This study examines the demographic and health- and medical cannabis-related factors associated with ...
Lynda G. Balneaves, Ashleigh Brown, Matthew Green, Erin Prosk, Lucile Rapin, Max Monahan-Ellison, Eva McMillan, Jonathan Zaid, Michael Dworkind, Cody Z. Watling   +9 more
doaj   +1 more source

Cannabis legalization and driving under the influence of cannabis in a national U.S. Sample

Preventive Medicine Reports, 2022
The relationship between cannabis legalization and traffic safety remains unclear. Physiological measures of cannabis impairment remain imperfect. This analysis used self-report data to examine the relationship between cannabis legalization and driving ...
Lauren M. Dutra, Matthew Farrelly, Camille Gourdet, Brian Bradfield   +3 more
doaj   +1 more source

CYP4X1/sEH‐Dependent Endocannabinoid Metabolism Drives Fibroblast‐Mediated Immunosuppression to Limit Immunotherapy in Colon Cancer

Advanced Science, EarlyView.
A proposed mechanism to explain the role of CYP4X1/sEH‐14,15‐EET‐EA system in colon cancer immune escape. 14,15‐EET‐EA, 14,15‐epoxyeicosatrienoic acid‐ethanolamide; sEH, soluble epoxide hydrolase; CYP4X1, cytochrome P450 4X1; GPR119, G‐protein coupled receptor 119; EGFR, epidermal growth factor receptor; Gs, Gαs subunit; cAMP, cyclic adenosine ...
Min Mo, Xuewei Chen, Yanzhuo Liu, Chenlong Wang, Xuehan Chen, Nan Zhang, Nan He, Ying Li, Jingyi Wang, Honglei Chen, Jing Yang   +10 more
wiley   +1 more source

Cannabidiol’s cytotoxicity in pancreatic cancer is induced via an upregulation of ceramide synthase 1 and ER stress

Journal of Cannabis Research
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive malignancies with a median 5 year-survival rate of 12%. Cannabidiol (CBD) has been found to exhibit antineoplastic potential and may potentiate the anticancer effects of cytotoxic’
Nagina Mangal, Vikash Reebye, Nagy Habib, Mikael H. Sodergren   +3 more
doaj   +1 more source

High CBD extract (CBD-X) modulates inflammation and immune cell activity in rheumatoid arthritis

Frontiers in Immunology
IntroductionRheumatoid arthritis (RA) is a debilitating autoimmune disease affecting approximately 1% of the global population and is associated with significant morbidity and mortality.
Miran Aswad, Antonina Pechkovsky, Narmeen Ghanayiem, Haya Hamza, Igal Louria-Hayon, Igal Louria-Hayon   +5 more
doaj   +1 more source