Results 51 to 60 of about 2,415,362 (310)

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi, Daisuke Katagiri, Takeyuki Watadani, Shunichi Matsuda, Hiroshi Kaneko, Noritoshi Arai   +5 more
wiley   +1 more source

The Effects of Outdoor Air Pollutants on the Costs of Stroke Hospitalizations in China [PDF]

, 2019
Stroke, the most frequent cause of severe disability and the second cause of death among adults in the world, brings tremendous mental and economic burden to patients and their families.
Chen, Fang, Li, Luo, Zeng, Siyu
core   +1 more source

The Debrisoft ® monofilament debridement pad for use in acute or chronic wounds: A NICE medical technology guidance [PDF]

, 2015
As part of its Medical Technology Evaluation Programme, the National Institute for Health and Care Excellence (NICE) invited a manufacturer to provide clinical and economic evidence for the evaluation of the Debrisoft ® monofilament debridement pad for ...
A Piaggesi, AW Goode, B Campbell, Catherine Meads, D Gray, D Williams, Eleonora Lovato, F Smith, I Michiels, J Edwards, J Stephen-Haynes, J White, JC Dumville, JC Dumville, JFP Posnett, JL Jensen, K Withers, Louise Longworth, M Bradley, M Doerler, MO Soares, P Raynor, PA D’Hemecourt, R Strohal, RG Brunner, S Bahr, S Johnson   +26 more
core   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Treatment of Chemical Dependency May Reduce Medical Utilization and Costs [PDF]

, 2006
Summarizes a study of the impact of chemical dependency treatment on the costs and utilization of medical services -- hospital days, emergency department visits, and outpatient visits.
Lauren Necochea, Lawrence Walter, Lynn Ackerson, Steven Allen   +3 more
core  

Factors associated with costs of hospitalization of severely mentally Ill patients [PDF]

, 2016
Background: Efforts to contain costs associated with general medical care include particular efforts for psychiatric disorders. Hospitalization represents the largest component of costs for psychiatric care and there is growing interest in balancing ...
Baldessarini, RossJ, Centorrino, Franca, Curto, Martina, Girardi, Paolo, Masters, Grace A   +4 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Robust Appointment Scheduling with Heterogeneous Costs [PDF]

, 2019
Designing simple appointment systems that under uncertainty in service times, try to achieve both high utilization of expensive medical equipment and personnel as well as short waiting time for patients, has long been an interesting and challenging ...
Schulz, Andreas S., Udwani, Rajan
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source