Results 61 to 70 of about 1,613,161 (302)

In situ synthesis of silver nanoparticles on the surface of PDMS with high antibacterial activity and biosafety toward an implantable medical device

Nano Convergence, 2017
We developed a straightforward method to fabricate antibacterial silicon films via the in situ synthesis of silver nanoparticles (AgNPs) on a polydimethylsiloxane (PDMS) film.
Joong Hyun Kim, HyeungWoo Park, Soo Won Seo   +2 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Selective detection of gaseous ammonia with specifically functionalized silicon photonic microring resonator: towards low cost and portable breath monitoring [PDF]

, 2013
We demonstrate a selective ammonia sensor based on a silicon photonic microring resonator functionalized with nanoporous silicate films. The potential of this sensor as a low cost, portable and real-time medical breath monitoring device is ...
Baets, Roel, Detavernier, C, Hens, Zeger, Levrau, E, Martens, JA, Sree, SP, Yebo, Nebiyu Adello   +6 more
core  

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Medical device software as a subsystem of an overall medical device [PDF]

, 2015
Embedded software is a sub-system that needs to be integrated with the electrical and mechanical subsystems for a functional medical device to be developed and marketed.
Clarke, Paul, Lepmets, Marion, McCaffery, Fergal   +2 more
core  

Prediction of Myasthenia Gravis Worsening: A Machine Learning Algorithm Using Wearables and Patient‐Reported Measures

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare disorder characterized by fluctuating muscle weakness with potential life‐threatening crises. Timely interventions may be delayed by limited access to care and fragmented documentation. Our objective was to develop predictive algorithms for MG deterioration using multimodal telemedicine data ...
Maike Stein, Haoqi Sun, Sophie Lehnerer, Lea Gerischer, Maximilian Mönch, Christian Meisel, Andreas Meisel, Pushpa Narayanaswami   +7 more
wiley   +1 more source

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

Characterization of Dynamic Gripping Force Feedback for Robot-Assisted Surgery

Current Directions in Biomedical Engineering
Haptic feedback of gripping forces during robotassisted surgery can benefit the surgical outcome by means of reduced forces applied to the tissue. A custom-designed haptic user interface allows to control four degrees of freedom of the instrument’s ...
Schäfer Max B., Riepe Sarah, Parenzan Matthias, Bauer Christian J. E., Hotz Jonas, Meiringer Johannes G., Weiland Sophie, Pott Peter P.   +7 more
doaj   +1 more source

Heart Rate Variability: A possible machine learning biomarker for mechanical circulatory device complications and heart recovery [PDF]

, 2020
Cardiovascular disease continues to be the number one cause of death in the United States, with heart failure patients expected to increase to \u3e8 million by 2030.
Aras, Shravan, Khalpey, Zain, Lin, Theodore   +2 more
core   +1 more source

The relation between patient discomfort and uncompensated forces of a patient support device for breast and regional lymph node radiotherapy [PDF]

, 2018
Although many authors stated that a user-centred design approach in medical device development has added values, the most common research approach within healthcare is evidence-based medicine, which tend to focus on functional data rather than patient ...
Boute, Bert, De Neve, Wilfried, Detand, Jan, Speleers, Bruno, Van de Velde, Joris, Van Greveling, Annick, Van Hoof, Tom, Veldeman, Liv, Vercauteren, Tom   +8 more
core   +2 more sources