Results 51 to 60 of about 1,082,905 (306)
Design Study of Medical Device [PDF]
, 2019 Intense competition has become the norm in most markets in recent years, due to globalization and technology advancements among other reasons [1–3]. Therefore, it is an essential necessity for firms that want to stay relevant and competitive, to seek innovation and creativity in new product development (NPD) process, while trying to maintaining high ...
Burcu Taşkın +3 more
openaire +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Design, implementation, and management of an international medical device registry
Trials, 2021 Background Registries are powerful clinical investigational tools. Although in hospitals registries may be mandated, industry-sponsored, international registries are voluntary and therefore can require clearer objectives and more planning.
Herbert Mauch +3 more
doaj +1 more source
User needs elicitation via analytic hierarchy process (AHP). A case study on a Computed Tomography (CT) scanner [PDF]
, 2013 Background: The rigorous elicitation of user needs is a crucial step for both medical device design and purchasing. However, user needs elicitation is often based on qualitative methods whose findings can be difficult to integrate into medical decision ...
A Chapple +64 more
core +4 more sources
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Patient experience of negative pressure wound therapy: A qualitative study
Nursing Open, 2023 Aim This study aimed to clarify the treatment experience of patients undergoing negative pressure wound therapy (NPWT). Design This study used a qualitative design.
Aiko Miyanaga +5 more
doaj +1 more source
On the Deployment of Healthcare Applications over Fog Computing Infrastructure [PDF]
, 2017 Fog computing is considered as the most promising enhancement of the traditional cloud computing paradigm in order to handle potential issues introduced by the emerging Interned of Things (IoT) framework at the network edge. The heterogeneous nature, the
Akrivopoulos, Orestis +3 more
core +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Inhibition of bacterial adhesion on medical devices [PDF]
, 2011 Microbial infections resulting from bacterial adhesion to biomaterial surfaces have been observed on almost all medical devices. Biofilm infections pose a number of clinical challenges due to their resistance to immune defence mechanisms and ...
Rodrigues, L. R.
core +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source