Results 71 to 80 of about 15,704,965 (277)

Hands-on engineering courses in the COVID-19 pandemic: adapting medical device design for remote learning. [PDF]

Phys Eng Sci Med, 2021
Liu Y, Vijay A, Tommasini SM, Wiznia D.
europepmc   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

A mechanical device for precise self-administration of ocular drugs

Human Factors in Healthcare
Individuals with glaucoma are routinely prescribed and required to self-administer eye drop-based medication multiple times a day. Unfortunately, the process of self-administering eye drops requires a level of dexterity, strength, and visual acuity that ...
Jesse George-Akpenyi, Benjamin Lahner, Seung Hyeon Shim, Carly Smith, Nakul Singh, Matt Murphy, Leroy Sibanda, Giovanni Traverso, Nevan C. Hanumara   +8 more
doaj   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

User involvement in healthcare technology development and assessment: Structured literature review [PDF]

, 2006
Purpose – Medical device users are one of the principal stakeholders of medical device technologies. User involvement in medical device technology development and assessment is central to meet their needs.
Ian Robinson, Shah, SGS, Syed Ghulam Sarwar Shah, Robinson, I   +3 more
core   +1 more source

The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp, Ludwig Karrasch, Helena Breitenstein, Andreas Straube, Katharina Kamm   +4 more
wiley   +1 more source

Using simulation to explore the impact of device design on the learning and performance of peripheral intravenous cannulation

Advances in Simulation, 2019
Background The design of medical devices impacts upon the performance of healthcare professionals and patient safety. However, multiple devices serving the same function are often available.
Bronwyn Reid-McDermott, Maryanne Browne, Dara Byrne, Paul O’Connor, Emily O’Dowd, Chloe Walsh, Caoimhe Madden, Sinéad Lydon   +7 more
doaj   +1 more source

Added Prognostic Value of EEG Reactivity in Comatose Patients Following Cardiac Arrest

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To evaluate the added prognostic value of EEG reactivity for favorable outcome compared with background analysis during and after targeted temperature management (TTM). Methods Prospective observational cohort study of comatose post–cardiac arrest patients admitted to a single academic center between 2017 and 2022, all undergoing ...
Sarah Caroyer, Marie Obrecht, Charlotte de Maeseneire, Charlotte Damien, Chantal Depondt, Lorenzo Ferlini, Estelle Rikir, Filippo Annoni, Fabio Silvio Taccone, Nicolas Mavroudakis, Benjamin Legros, Nicolas Gaspard   +11 more
wiley   +1 more source

Shear Resistance and Surface Design of 3D Printed Dowels Made from Different Materials in Glued Scots Pine Furniture Joints

BioResources
The shear resistance was measured for Scots pine (Pinus sylvestris) furniture joints assembled using straight, cross, and grooved-patterned dowels fabricated via 3D printing with Poly Lactic Acid (PLA), tough PLA, Poly Amide (PA), and tough resin ...
Samet Demirel, Barış Koylu, Nada Mteraf, Kutay Çava, Mustafa Aslan   +4 more
doaj  

Design and evaluation of a ball spline wasp-inspired needle

Frontiers in Bioengineering and Biotechnology
In percutaneous interventions, needles are used to reach target locations inside the body. However, when the needle is pushed through the tissue, forces arise at the needle tip and along the needle body, making the needle prone to buckling.
Jette Bloemberg, Zola Fung-A-Jou, Paul Breedveld, Aimée Sakes   +3 more
doaj   +1 more source