Results 71 to 80 of about 1,082,905 (306)

Human Factors Standards and the Hard Human Factor Problems: Observations on Medical Usability Standards [PDF]

, 2020
With increasing variety and sophistication of computer-based medical devices, and more diverse users and use environments, usability is essential, especially to ensure safety. Usability standards and guidelines play an important role. We reviewed several,
Gadala, M., Strigini, L.
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

MEDICAL DEVICE DESIGN FOR LEG RECOVERY

Journal of Industrial Design and Engineering Graphics, 2010
This paper informs about medical devices design and their importance for people’s health. It analyses two leg recovery devices and a new option regarding to a personal device design.
BEREZA Gianina, MARIN Dumitru
doaj  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

A Medical Waste Sterilizer [PDF]

, 2010
Sterilization of medical waste is very important for the environment, as the exposition may result in various diseases because of viral or bacterial content of the waste.
Coskun, E.
core  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Design strategies for flexible core biopsy needles: insights from patent literature

Frontiers in Medical Technology
Flexible biopsy needles are essential for minimally invasive cancer diagnostics, enabling core biopsy sampling through endoscopic and catheter-based procedures.
Nynke M. Ansems, Nynke M. Ansems, Dalibor Vasilic, Paul Breedveld   +3 more
doaj   +1 more source

A framework for designing medical devices resilient to low-resource settings

Globalization and Health, 2021
Background To date (April 2021), medical device (MD) design approaches have failed to consider the contexts where MDs can be operationalised. Although most of the global population lives and is treated in Low- and Middle-Income Countries (LMCIs), over 80%
Davide Piaggio, Rossana Castaldo, Marco Cinelli, Sara Cinelli, Alessia Maccaro, Leandro Pecchia   +5 more
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Design and evaluation of new user control devices for improved ergonomics in flexible robotic endoscopy

Frontiers in Robotics and AI
BackgroundThe ergonomics of flexible endoscopes require improvement as the current design carries a high risk of musculoskeletal injury for endoscopists.
Leander Heisterberg, Leander Heisterberg, Luigi Manfredi, Dörte Wichmann, Thomas Maier, Peter P. Pott   +5 more
doaj   +1 more source