Results 81 to 90 of about 1,082,905 (306)

Heart Rate Variability: A possible machine learning biomarker for mechanical circulatory device complications and heart recovery [PDF]

open access: yes, 2020
Cardiovascular disease continues to be the number one cause of death in the United States, with heart failure patients expected to increase to \u3e8 million by 2030.
Aras, Shravan   +2 more
core   +1 more source

Increasing compliance with wearing a medical device in children with autism [PDF]

open access: yes, 2019
Health professionals often recommend the use of medical devices to assess the health, monitor the well-being, or improve the quality of life of their patients.
Athens E. S.   +22 more
core   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

open access: yesFEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen   +6 more
wiley   +1 more source

Fractal geometry of nature (bone) may inspire medical devices shape [PDF]

open access: yes, 2010
Medical devices, as orthopaedics prostheses and dental implants, have been designed over years on the strength of mechanical, clinical and biological indications.
Matteo Sartori, Salvatore Longoni
core   +1 more source

Ultrasonic needles for bone biopsy [PDF]

open access: yes, 2017
Bone biopsy is an invasive clinical procedure where a bone sample is recovered for analysis during the diagnosis of a medical condition. When the architecture of the bone tissue is required to be preserved, a core-needle biopsy is taken.
Cleary, Rebecca   +5 more
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

The CMS Si-strip Tracker

open access: yes, 2004
The Compact Muon Solenoid (CMS) experiment at LHC features the largest Silicon Strip Tracker (SST) ever build. This device is immersed in a 4T magnetic field and, in conjunction with a Pixel system, it allows the momentum of the charged particles to be ...
Sguazzoni, Giacomo
core   +2 more sources

Managing the variability of biomechanical characteristics before the preliminary design stage of a medical device [PDF]

open access: yes, 2014
The very high level of requirements for certification procedures often limit research and development departments to innovate using increments and iterations during the design process for medical devices (MD).
MESNARD, Michel   +2 more
core   +3 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Integrating the results of user research into medical device development: insights from a case study

open access: yesBMC Medical Informatics and Decision Making, 2012
Background It is well established that considering users is an important aspect of medical device development. However it is also well established that there are numerous barriers to successfully conducting user research and integrating the results into ...
Martin Jennifer L, Barnett Julie
doaj   +1 more source

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