Results 121 to 130 of about 10,124,616 (311)
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
ChemosensorsBio-sniffers represent a novel detection technology that demonstrates significant potential in medical diagnostics. Specifically, they assess disease conditions and metabolic status through the detection of volatile organic compounds (VOCs) in exhaled ...
Yang Wang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Sensitivity of Bayesian Networks to Noise in Their Parameters
EntropyThere is a widely spread belief in the Bayesian network (BN) community that the overall accuracy of results of BN inference is not too sensitive to the precision of their parameters.
Agnieszka Onisko, Marek J. Druzdzel
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Sensitivity of Bayesian Networks to Errors in Their Structure
EntropyThere is a widespread belief in the Bayesian network (BN) community that while the overall accuracy of the results of BN inference is not sensitive to the precision of parameters, it is sensitive to the structure.
Agnieszka Onisko, Marek J. Druzdzel
doaj +1 more source
, 1953 This glass lantern slide features a map of the Medical Colleg of South Carolina Medical Center campus in ...
Medical College of South Carolina (1952-1969). Department of Medical Illustration
core
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
A Novel Picture Fuzzy Similarity Measure: Theory and Practical Applications
IEEE AccessSimilarity metrics serve as valuable tools for evaluating the resemblance between two datasets. While intuitionistic fuzzy sets have been widely used, picture fuzzy sets present enhanced capabilities in capturing ambiguity and uncertainty within real ...
Abdul Haseeb Ganie +3 more
doaj +1 more source