Results 71 to 80 of about 4,322,490 (338)

Modelling and simulation of magnetic induction in magnetic particle imaging system [PDF]

, 2020
In the last century, tomographic imaging has become an essential tool for disease diagnosis. There are several dominant tomographic imaging methods used for medical application such as computed tomography (CT), magnetic resonance imaging (MRI), positron ...
Birahim, Muhamad Fikri Shahkhirin, Othman, Nurmiza, Sapuan, Syarfa’ Zahirah   +2 more
core  

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Service Delivery in Substance Abuse Treatment: Reexamining "Comprehensive" Care [PDF]

, 2008
Outlines findings on organizational characteristics linked with comprehensive services -- core diagnosis and treatment and wraparound services, including transportation and childcare assistance or legal, financial, employment, or medical ...
Deanna Lewis, Lori J. Ducharme
core  

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Resilience-aware MLOps for AI-based medical diagnostic system

Frontiers in Public Health
BackgroundThe healthcare sector demands a higher degree of responsibility, trustworthiness, and accountability when implementing Artificial Intelligence (AI) systems.
Viacheslav Moskalenko, Vyacheslav Kharchenko   +1 more
doaj   +1 more source

Approximate inference for medical diagnosis [PDF]

Pattern Recognition Letters, 1999
Abstract Computer-based diagnostic decision support systems (DSSs) will play an increasingly important role in health care. Due to the inherent probabilistic nature of medical diagnosis, a DSS should preferably be based on a probabilistic model.
Wiegerinck, W.A.J.J., Kappen, H.J., Braak, E.W.M.T. ter, Burg, W.J.P.P. ter, Nijman, M.J., O, Y.l., Neijt, J.P.   +6 more
openaire   +4 more sources

MDNet: A Semantically and Visually Interpretable Medical Image Diagnosis Network

, 2017
The inability to interpret the model prediction in semantically and visually meaningful ways is a well-known shortcoming of most existing computer-aided diagnosis methods.
McGough, Mason, Xie, Yuanpu, Xing, Fuyong, Yang, Lin, Zhang, Zizhao   +4 more
core   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Autism Data Classification Using AI Algorithms with Rules: Focused Review

Bioengineering
Autism Spectrum Disorder (ASD) presents challenges in early screening due to its varied nature and sophisticated early signs. From a machine-learning (ML) perspective, the primary challenges include the need for large, diverse datasets, managing the ...
Abdulhamid Alsbakhi, Fadi Thabtah, Joan Lu   +2 more
doaj   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source