Results 111 to 120 of about 534,214 (313)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Medicina, educação e gênero: as diferenciações sexuais do suicídio nos discursos médicos do século XIX Medicine, education and gender: suicide sexual differences in the XIX century medical discourses

Educar em Revista, 2007
Por meio deste artigo, analiso as diferenciações sexuais, constantes e recorrentes em discursos médicos do século XIX, entre o suicídio cometido por homens daquele cometido por mulheres.
Fábio Henrique Lopes
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

In search of the Plague. The Greek Peninsula Faces the Black Death, 14th to 19th Centuries [PDF]

, 1998
Histories of the plague are based on the belief that we can locate epidemia in the related sources and classify them according to present-day medical categories.
Kostis, Kostas P.
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Anaphora Issue in Medical Discourse

Acta Marisiensis. Philologia, 2019
Abstract The assertion from which we start our study is that in the last decades the anaphor has been defined relatively homogeneously from one researcher to another, from two perspectives: a. The syntactical-semantic perspective; and b.
openaire   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Echoes of Krafft-Ebing’s Psychopathia Sexualis in Scientific Periodicals: Sexual and Mental Pathology in Late Nineteenth- and Early Twentieth Century Medical Discourse

Lea
This essay proposes a corpus-based terminological analysis of the language of moral decadence, sexual deviance and mental degeneration introduced and/or popularised by Richard von Krafft-Ebing’s Psychopathia Sexualis.
Annalisa Federici
doaj   +1 more source

Сommunicative toxicity in medical discourse

Communication Studies
The article is devoted to the problem of toxic communication in the medical sphere. Toxicity, as a new phenomenon of communication, is of particular interest in the context of increased attention of researchers to the pragmatic side of spoken interaction.
Gayane Melkonyan, Elena Nagieva
openaire   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source