Results 131 to 140 of about 534,214 (313)
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Enriched property ontology for knowledge systems : a thesis presented in partial fulfilment of the requirements for the degree of Master of Information Systems in Information Systems, Massey University, Palmerston North, New Zealand [PDF]
, 2006 "It is obvious that every individual thing or event has an indefinite number of properties or attributes observable in it and might therefore be considered as belonging to an indefinite number of different classes of things" [Venn 1876].
Minchin, Robert
core
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Актуальні питання суспільних наук та історії медицини, 2014 Orobchuk Dariia. Social role, communicative, structural and semantic features of medical institutional discourse. The article describes the main aspects of study of medical communication, defines the place of medical discourse in the system of ...
Оробчук Дарія
doaj
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
On the regularity of metonymy across languages (exemplified on some metonymies in medical discourse
ExELL (Explorations in English Language and Linguistics)The topic of metonymy regularity has cropped up in several recent articles, a welcome sign of growing interest in this phenomenon, which may eventually contribute towards shedding more light on the phenomenon of metonymic competence, paralleling ...
Mario Brdar
doaj
Актуальні питання суспільних наук та історії медицини, 2016 Shutak L., Navchuk G. Cognitive Metaphor as a Means of Creating Secondary Nominations Medical Discourse. Lexical organization of any language is characterized not only by correlation of existing language lexicalsemantic units, but also by the ...
Лариса ШУТАК +1 more
doaj
Attending Rounds: The HumptyDumptification of Medical Discourse. [PDF]
J Grad Med Educ, 2016 Neelon FA.
europepmc +1 more source