Results 61 to 70 of about 165,721 (260)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Assessment of Alborz University of Medical Sciences Dental Students\' Knowledge of Medical Emergencies [PDF]

نشریه دانشگاه علوم پزشکی البرز
Background and Aim: Lack of necessary awareness and misdiagnosis can have serious consequences in dental emergencies, potentially causing irreparable harm to the patient's health. This study aimed to assess dental students' knowledge at Alborz University
Maryam Aghabarary, Mahsa Khedmatizare, Ali Esmaeili, Iman Shirinbak, Roohangiz Norouzinia   +4 more
doaj  

Evaluation of the Consequences and Costs of the Anglo-American System in the Pre-Hospital Emergency Department of Yazd in 2018

Journal of Evidence Based Health Policy, Management & Economics, 2023
Background: One of the most important tasks of health care managers is  allocateing resources, controling them and ensuring their effective use when available. This study examines the consequences and costs of emergency services in Yazd in 2018. Methods:
Mohsen Pakdaman, Roohollah Askari, Ahmad Dehghan, Saeedreza Pahlavanpoor, Alireza Nikafshan   +4 more
doaj  

Cardio-pulmonary resuscitation challenges in selected Botswana hospitals: Nurse managers’ views

Health SA Gesondheid: Journal of Interdisciplinary Health Sciences, 2013
Road traffic accident victims, as well as persons experiencing cardiac and other medical emergencies, might lose their lives due to the non-availability of trained personnel to provide effective cardio-pulmonary resuscitation (CPR) with functional ...
Lakshmi Rajeswaran, Valerie J. Ehlers
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

An Emerging Medical Giant

JACC: Cardiovascular Interventions, 2013
![Figure][1] My first trip to southern India was in the early 1990s at the beginning of the stent era. The conference featured speakers from around the world talking about the advantages of the stents that were available and several that were in development.
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Significations plurielles des urgences médicales et chirurgicales. Étude sociologique au service des UMC au CHU d’Oran

إنسانيات, 2018
Medical emergencies are being imbued with an ambiguity in status and profession, a structural gap in their functionning, and a medical and organizational « bankruptcy ».The emergencies, which primary mission is only to providing care for the sick persons
Abdelkrim Haouari, Abdelmalek Adda Boudjellel   +1 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source