Results 61 to 70 of about 6,920,159 (258)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

The Australian emergency medical system

, 2008
The Australian emergency medical system has transformed over the last thirty years with the development of pre-hospital care services, hospital Emergency Departments and the development of new professional roles of Emergency Physician and Paramedic. This
Hang, H., FitzGerald, Gerard, Hou, Xiang-Yu   +2 more
core   +1 more source

RELATIONSHIP BETWEEN NURSE RESPONSE TIME AND HEMODYNAMIC VALUES IN PATIENTS WITH HYPOVOLEMIC SHOCK

Journal of Vocational Nursing
Introduction: Response time for nurses in the emergency department is critical because delays in treating patients with hypovolemic shock can significantly worsen the patient’s condition within minutes, leading to reduced perfusion that causes ...
Ahmad Hasan Basri, Ony Suhandhi, Abdul Manan   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Emergency Medical Services Voluntary Recognition Program

, 2014
Title from caption."The Kansas Board of Emergency Medical Services has established a voluntary program to recognize those EMS services going above and beyond to better serve the citizens of their community.
Kansas. Board of Emergency Medical Services.
core  

Lean emergency medical operations [PDF]

, 2017
The fundamental responsibilities of Emergency Medical Service (EMS) systems are to provide urgent medical care, such as pre-hospital care, and to transport the patient to the hospital if needed.
Bastidas, Ana Cristina, Villarreal, Bernardo, Garza-Reyes, Jose Arturo, Lankenau, Andrea Montalvo, Granda, Edgar   +4 more
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Challenges with Life-Threatening Injuries in the Room of Reanimation.

Albanian Journal of Trauma and Emergency Surgery
Introduction: Patients with life-threatening injuries are a significant concern in the emergency department (ED). These injured people require timely care, as their lives depend on it, and a longer wait can result in organ failure, irreversible damage ...
Basri Lenjani, Agron Dogjani, Nuhi Arslani, Ilirian Lenjani   +3 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Relationship between Occupational Stress and Mental Health in Male Personnel of Medical Emergency in Golestan Province

Journal of Research Development in Nursing and Midwifery, 2015
Background and Objective: One of the environmental factors bringing about chronic stress is something that is related to occupation. Because mental health improvement of a society particularly in a productive group is a necessity for dynamics and ...
Zahra Moshtagh Eshgh, Ali Akbar Aghaeinejad, Akram Peyman, Aref Amirkhani, Maryam Chehregosha   +4 more
doaj