Results 151 to 160 of about 6,257,121 (349)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

A comparison between conflict of interest in Western and Islamic literatures in the realm of medicine.

Journal of Medical Ethics and History of Medicine, 2015
In Western literatures, "conflict" is a general term that refers to discord between two or more entities. In Islamic jurisprudence, however, in addition to the term "conflict" (Taāruz), there is another term which is called tazāhum.
Mojtaba Parsa, Kiarash Aramesh, Bagher Larijani   +2 more
doaj  

Situações de conflitos éticos relevantes para a discussão com estudantes de Medicina: uma visão docente

Revista Brasileira de Educação Médica
A formação ética e humanística dos estudantes de Medicina vem sendo bastante valorizada e questionada na atualidade. A discussão dos conflitos éticos que surgem durante o exercício da medicina é uma das estratégias de maior impacto para o desenvolvimento
Aluisio Marçal de Barros Serodio, José Antônio Maia de Almeida   +1 more
doaj   +1 more source

A New Direction for Teaching Medical Ethics [PDF]

, 1970
Eun Sul Lee, Mi Sook Song, Ki Young Lim, Ho Young Lee   +3 more
openalex   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Journal of Medical Ethics and History of Medicine Contributors

Journal of Medical Ethics and History of Medicine, 2021
Journal of Medical Ethics & History of Medicine
doaj  

Medical Ethics; or a Code of Institutes and Precepts adapted to the Professional Conduct of Physicians and Surgeons [PDF]

openalex   +1 more source

New horizons in medical ethics. Research investigations and the fetus. [PDF]

, 1973
R. W. Smithells, R. W. Beard
openalex   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Medical Students’ and Interns’ Attitudes toward Medical Ethics Education in a Thai Medical School

Siriraj Medical Journal, 2016
Background: Medical ethics has been accepted as part of every accredited medical curriculum for the past 40 years. Medical students’ attitudes have an important role for development and improvement of the curriculum.
Sakda Sathirareuangchai
doaj