Results 201 to 210 of about 2,040,332 (267)

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

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The Medical Examiner in War

Journal of Forensic Sciences, 1995
Abstract Loss of human life is one of the tragic costs of war. While combat deaths are expected, non-combat deaths during a military operation often come as a surprise to military planners and the public. During Operation Desert Storm, all United States deaths related to the Gulf War were classified according to circumstances as either ...
K B, Reiber, A C, Burns, D W, Oxley, W T, Gormley   +3 more
openaire   +2 more sources

The independent medical examination

Physical Medicine and Rehabilitation Clinics of North America, 2002
The physiatrist, owing to expertise in impairment and disability analysis, is able to offer the medicolegal process considerable assistance. This chapter describes the scope and process of the independent medical examination (IME) and provides an overview of its component parts.
Arthur, Ameis, Nathan D, Zasler
openaire   +2 more sources

Timing of the Medical Examination

Journal of Child Sexual Abuse, 2011
The medical examination of the sexually abused child may have evidentiary, medical, and therapeutic purposes, and the timing of the examination requires consideration of each of these objectives. In cases of acute sexual assault, emergent examinations may be needed to identify injury, collect forensic evidence, and provide infection and pregnancy ...
openaire   +2 more sources

Preemployment Medical Examinations

JAMA: The Journal of the American Medical Association, 1982
To the Editor.— In the response of T. Forrest Fisher, MD (1982;247:1407), to the letter from Joseph L. Crumrine, MD, regarding inguinal hernias and employment, Dr Fisher suggests that the decision of the physician to waive restrictions relative to an employee with an inguinal hernia should include consideration of Equal Employment Opportunity ...
openaire   +2 more sources

Examinations and the Medical Literature

Annals of Internal Medicine, 1986
Excerpt To the editor: Two articles in the July issue illustrate the ever-increasing gulf between academic medicine and the practice of general internists.
openaire   +2 more sources