Results 151 to 160 of about 88,942 (301)

Unification and Reorganization of the United States Medical Examiner and Coroner Systems

, 2017
: In 2009 the National Academy of Sciences issued a publication outlining current issues in forensic science as well as key recommendations to fix relevant problems in fields ranging from comparative forensics to the death investigation system itself ...

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IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Medical Examiner/Coroner Death Investigation Data Set (McDIDS) [PDF]

A guideline for medical examiner and coroner offices to promote greater similarity among the electronic data bases used in different death investigation offices in order to facilitate mortality monitoring and ...

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Medical Examiner Review of the Characteristics of Fire-Related Homicides. [PDF]

Acad Forensic Pathol, 2020
Conway KS, Schmidt CJ, Brown TT.
europepmc   +1 more source

Exploring the contextual risk factors and characteristics of individuals who died from the acute toxic effects of opioids and other illegal substances: listening to the coroner and medical examiner voice. [PDF]

Health Promot Chronic Dis Prev Can, 2023
Thompson T, Rotondo J, Enns A, Leason J, Halverson J, Huyer D, Kuo M, Lapointe L, May-Hadford J, Orpana H.   +9 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Moving Toward a More Uniform System: Recommendations for Minimum Standards of Medical Examiner Offices in Texas

, 2013
Research Purpose: Texas operates a two-tiered system for certification of deaths. Elected officials with no scientific background determine and certify cause of death for residents in the majority of Texas counties.
Adame-Wilson, Romy
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Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Mapping the overdose crisis: 6 locations using open medical examiner data. [PDF]

JAMIA Open
Harris DR, Anthony N, Keyes KA, Delcher C.   +3 more
europepmc   +1 more source