Results 231 to 240 of about 88,942 (301)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

A reliability assessment of the basic erosive wear examination and the tooth wear evaluation system 2.0 utilizing intraoral scan data. [PDF]

PLoS One
Lorens M, Tomaszewska I.
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Comparative Evaluation of Shade Selection Reliability: Visual Assessment, Intraoral Scanning, and Photographic Techniques. [PDF]

Int J Dent
Atri F, Rahmani F, Memarian M, Pirooz P.
europepmc   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

On the usefulness of Thompson´s test with a four-point scale after Achilles tendon rupture, a pilot study. [PDF]

BMC Musculoskelet Disord
Wetterteg AL, Riad J, Nordin P.
europepmc   +1 more source

Examiner stratification reveals clinically relevant variability in large language model answers to endodontic patient questions. [PDF]

Front Med (Lausanne)
Alqahtani SS, Algarni HA, Alonazi MA, Iqbal A, Khattak O, Jothish R, Karobari MI.   +6 more
europepmc   +1 more source

Operationalising readiness for practice in final OSCEs: insights from a mixed-methods study across five Australian medical schools. [PDF]

BMC Med Educ
Malau-Aduli BS, Saad S, Hays R, D'Souza K, Smith J, Williams B.   +5 more
europepmc   +1 more source

The reliability of the College of Intensive Care Medicine of Australia and New Zealand viva examination. [PDF]

Crit Care Resusc
Hoffman KR, Swanson D, Lane S, Nickson CP, Brand P, Ryan AT.   +5 more
europepmc   +1 more source