Results 121 to 130 of about 1,221,619 (355)
Теоретические и социокультурные предпосылки изучения наследственных заболеваний человека: историческая ретроспектива и современное положение [PDF]
, 2015 Рассмотрены процессы зарождения и становления медицинской генетики на основе анализа когнитивных и социокультурных факторов, оказавших влияние на развитие данной научной области.
Фандо, Р.А.
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Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source
A. G. Steinberg: Progress in Medical Genetics, vol. I. Published by Grune & Stratton, New York and London, 1961. 341 pages, 64 Tables, 30 Figs. [PDF]
, 1962 Paolo Parisi
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Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
Targeted RNA‐sequencing assays: a step forward compared to FISH and IHC techniques?
Cancer Medicine, 2019 Introduction ALK and ROS1 rearrangements are molecular targets of several tyrosine kinase inhibitors. RNA‐sequencing approaches are regarded as the new standard for fusion gene detection, representing an alternative to standard immunohistochemistry (IHC)
Gaëlle Tachon +7 more
doaj +1 more source
Medical genetics 1958–1960. An annotated review [PDF]
, 1962 Alexander G. Bearn
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Molecular Oncology, EarlyView.This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti +10 more
wiley +1 more source
Implementation of molecular karyotyping in clinical genetics
Zdravniški Vestnik, 2013 Rapid development of technologies for the study of the human genome is an expected step after the discovery and sequencing of the entire human genome.
Luca Lovrecic, Borut Peterlin
doaj
Molecular Oncology, EarlyView.Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit +19 more
wiley +1 more source