Results 141 to 150 of about 1,273,127 (279)

Medical genetics in South Africa. [PDF]

, 1990
T Jenkins
openalex   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Advancing CRISPR genome editing into gene therapy clinical trials: progress and future prospects

Expert Reviews in Molecular Medicine
Genome editing has recently evolved from a theoretical concept to a powerful and versatile set of tools. The discovery and implementation of CRISPR-Cas9 technology have propelled the field further into a new era.
Busra Cetin, Fulya Erendor, Yunus Emre Eksi, Ahter D. Sanlioglu, Salih Sanlioglu   +4 more
doaj   +1 more source

Molecular Research in Medical Genetics. [PDF]

Int J Mol Sci, 2022
Viggiano E.
europepmc   +1 more source

Medical genetics in Israel. [PDF]

, 1989
Richard M. Goodman, Batsheva Bonné‐Tamir, A. Adam, R. Voss, Gideon Bach, Yosef Shiloh, M B Katznelson, G Barkai, B. Goldman, B Padeh   +9 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

British Medical Genetics Conference. York, 12-14 September 1994. Abstracts. [PDF]

, 1995
Charis Eng, Lois M. Mulligan, Stanislas Lyonnet, Patrick Edery, Dean P. Smith, Jessica C. F. Kwok, Emily Gardner   +6 more
openalex   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Improving medical students' knowledge of genetic disease: a review of current and emerging pedagogical practices

Advances in Medical Education and Practice, 2015
Michael J Wolyniak,1 Lynne T Bemis,2 Amy J Prunuske2 1Department of Biology, Hampden-Sydney College, Hampden-Sydney, VA, 2Department of Biomedical Sciences, University of Minnesota Medical School, Duluth, MN, USA Abstract: Genetics is an essential ...
Wolyniak MJ, Bemis LT, Prunuske AJ
doaj  

Elivaldogene autotemcel approved for treatment of cerebral adrenoleukodystrophy (CALD) in males: A therapeutics bulletin of the American College of Medical Genetics and Genomics (ACMG). [PDF]

Genet Med Open, 2023
Scott AI, Mallhi KK, Ganesh J, Chen WL, ACMG Therapeutics Committee8∗documents@acmg.net.   +4 more
europepmc   +1 more source