Results 31 to 40 of about 2,275,397 (311)

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

open access: yesFEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao   +7 more
wiley   +1 more source

The First Medical Text in Preventive Medicine Written in Islamic World

open access: yesJournal of Research on History of Medicine, 2014
Medical books written in Islamic societies have devoted special chapters to preventive medicine named Hefzossehha’. Nowadays, Ferdous Alhekmah is considered as the first medical text authored by Muslim scientists in Islamic countries.
Seied Saeid Esmaeili   +3 more
doaj  

Collecting COVID-19 at National Museums Scotland

open access: yesMuseum & Society, 2020
This opinion piece discusses National Museums Scotland’s first responses to collecting COVID-19. Drawing on perspectives from social history, biomedical science and military history, this short paper contextualizes COVID-related collecting within the ...
Sarah Laurenson   +2 more
doaj   +1 more source

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

open access: yesFEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi   +5 more
wiley   +1 more source

A contemporary review of breast cancer risk factors and the role of artificial intelligence

open access: yesFrontiers in Oncology
BackgroundBreast cancer continues to be a significant global health issue, necessitating advancements in prevention and early detection strategies. This review aims to assess and synthesize research conducted from 2020 to the present, focusing on breast ...
Orietta Nicolis   +5 more
doaj   +1 more source

Differential Diagnostic Indicators for the Appointment of Non-Steroidal Anti-Inflammatory Therapy in the Treatment of Red Eye Syndrome at the Stage of Primary Outpatient Admission. Part 1

open access: yesOftalʹmologiâ, 2023
Every practicing ophthalmologist, regardless of the scope of their clinical and scientific interests, is faced with a dilemma — what treatment to prescribe to a patient who applied for a primary outpatient appointment with signs of red eye syndrome ...
V. N. Trubilin   +6 more
doaj   +1 more source

TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation

open access: yesFEBS Letters, EarlyView.
TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling   +4 more
wiley   +1 more source

THE USE OF PRECIOUS STONES FOR THERAPEUTIC PURPOSES IN MEDIEVAL ANATOLIAN TURKISH CIVILIZATION: THE CASE OF THE RUBY

open access: yesTürk Kültürü ve Hacı Bektaş Velî Araştırma Dergisi
Alongside narratives of the rarity, beauty, and value of rubies, owning assets (e.g. state, power) has also been expressed in the literature on medieval Anatolian Turkish literature with reference to rubies.
Meryem Gürbüz , Hüseyin Doğan
doaj   +1 more source

Goodbye flat lymphoma biology

open access: yesFEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria   +3 more
wiley   +1 more source

A historical overview on medical exchanges between China and Vietnam

open access: yesChinese Medicine and Culture, 2019
This article reviews the history of transmission and exchange of medicine between China and Vietnam. Systematic textual research found medical activities such as doctor visits, epidemics transmission, exchanges of therapies, import of local herbal, and ...
Chenxue Jiang, Boying Ma
doaj   +1 more source

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