Results 151 to 160 of about 492,068 (301)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Correlations between fabric tensors computed on cone beam and microcomputed tomography images

, 2013
Computational Vision and Medical Image Processing. VIPIMAGE 2013 contains invited lectures and full papers presented at VIPIMAGE 2013 - IV ECCOMAS Thematic Conference on Computational Vision and Medical Image Processing (Funchal, Madeira Island, Portugal,
Moreno, Rodrigo, Eva Klintström, Brismar, Torkel, Smedby, Örjan, Borga, Magnus, Torkel Brismar, Klintström, Eva, Magnus Borga, Örjan Smedby, Rodrigo Moreno   +9 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Representation and indexing of medical images

, 2011
The interpretation of an image by the computer is a highly complex task. There is a huge gap between the human and computational understanding of images and its interpretation. In this paper we present some of the concepts involved in the representation,
Moreno, Ramòn-Alfredo, Gutierrez, Marco-Antônio, Ramón Alfredo Moreno, Rebelo, Marina-de-Sá, Marina de Sá Rebelo, Marco Antônio Gutierrez   +5 more
core  

Explainable fully automated CT scoring of interstitial lung disease for patients suspected of systemic sclerosis by cascaded regression neural networks and its comparison with experts

Scientific Reports
Visual scoring of interstitial lung disease in systemic sclerosis (SSc-ILD) from CT scans is laborious, subjective and time-consuming. This study aims to develop a deep learning framework to automate SSc-ILD scoring.
Jingnan Jia, Irene Hernández-Girón, Anne A. Schouffoer, Jeska K. de Vries-Bouwstra, Maarten K. Ninaber, Julie C. Korving, Marius Staring, Lucia J. M. Kroft, Berend C. Stoel   +8 more
doaj   +1 more source

Impact of Upstream Medical Image Processing on Downstream Performance of a Head CT Triage Neural Network. [PDF]

Radiol Artif Intell, 2021
Hooper SM, Dunnmon JA, Lungren MP, Mastrodicasa D, Rubin DL, Ré C, Wang A, Patel BN.   +7 more
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

An overview of medical image processing methods

African Journal of Biotechnology, 2010
Maras, Hakan/0000-0001-5117 ...
Maras, Hakan Hadi, Maras, Yueksel, Maras, Erdem Emin, Aktug, Bahadir, Maras, Sueleyman Sirri, Yildiz, Ferruh   +5 more
openaire   +3 more sources