Results 81 to 90 of about 8,748,059 (256)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Quantification of Biophysical Parameters in Medical Imaging

open access: yes, 2018
This book provides a selection of essential knowledge on the image-based quantification of biophysical parameters for the purpose of clinical diagnosis.

core   +1 more source

Cognitive Constructivism in the Development of Medical Education [PDF]

open access: yes, 2020
This study introduces cognitive constructivism in reference to its emergence in the development of medical education. The main concepts of cognitive constructivism as they relate to knowledge construction and the learner’s process were described, and ...
Korean Medical Education Review (의학교육논단)
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Design of high frequency ultrasonic array transducers for medical imaging

open access: yes, 2011
Ultrasonic transducers have been widely used in the medical applications. High frequency array transducers have recently attracted many research interests, since it provides not only the electronic beamforming but also the very fine image resolution. The
Qian, Yichen
core   +1 more source

The Environmental Impact of Medical Imaging Agents and the Roadmap to Sustainable Medical Imaging

open access: yesAdvanced Science
Medical imaging agents, i.e., contrast agents for magnetic resonance imaging (MRI) and radiopharmaceuticals, play a vital role in the diagnosis of diseases.
Verena Pichler   +5 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

PET-MR medical imaging technology

open access: yesJournal of Associated Medical Sciences, 2013
Hybrid medical imaging technologies are originally occurred by a limitation of technology that is not giving clinical information completely in each one. Thus a further data acquisition by another modality is required.
Nathupakorn Dechsupa
doaj  

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

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