Results 21 to 30 of about 308,424 (248)
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Two h-Index Benchmarks for Evaluating the Publication Performance of Medical Informatics Researchers
Journal of Medical Internet Research, 2012 BackgroundThe h-index is a commonly used metric for evaluating the publication performance of researchers. However, in a multidisciplinary field such as medical informatics, interpreting the h-index is a challenge because researchers tend to have diverse
El Emam, Khaled +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
GMS Medizinische Informatik, Biometrie und EpidemiologieThe Heidelberg-Heilbronn medical informatics program, whose foundation and development during its first 50 years are reported here, was initially established in 1972 as a diploma program, then converted into a consecutive bachelor’s and master’s program ...
Haux, Reinhold
doaj +1 more source
Verpasste Chancen. Nachdenken über Fehlentwicklungen der Medizinischen Informatik
GMS Medizinische Informatik, Biometrie und Epidemiologie, 2023 Fifty years ago medical informatics in Germany was second to none, was world-leading along with Sweden and the USA. Today we are “also-rans” regarding the digitalisation in medicine, have a low ranking. What is the cause?
Giere, Wolfgang
doaj +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Applied Medical Informatics, 2023 The European Federation for Medical Informatics Association (EFMI) is the leading organisation in medical informatics in Europe and represents 29 countries, RSMI being an active and valuable member. EFMI is organized as a nonprofit organisation concerned
Lăcrămioara STOICU-TIVADAR +8 more
doaj
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
What is Medical Informatics? (Out of Print)
MedEdPORTAL, 2007 This web-based resource gives an overview of the medical informatics field, with a focus on the definition of medical informatics, the major applications, and the educational opportunities.
William Hersh
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source