Results 31 to 40 of about 4,513,419 (307)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

George Baillie on peptide array, a technique that transformed research on phosphodiesterases [PDF]

, 2015
George Baillie speaks to Francesca Lake (Managing Editor, Future Science OA). George Baillie is a Professor and PI within the Institute of Cardiovascular and Medical Sciences at the University of Glasgow (Glasgow, UK). His research over the last 15 years
Baillie, George S.
core   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Medical Laboratory Director Competencies: State of the Basic Medical Sciences and Global Perspective

پیاورد سلامت, 2017
Background and Aim: There has been a long-lasting debate among medical laboratory-associated specialists about required competencies and educational background to qualify for directing medical laboratories in Iran.
Mohammad Erfan Zare, Reza Meshkani, Mojtaba Abbasi, Farhad Shaveisi Zadeh, Atefeh Nasir Kansestani   +4 more
doaj  

A Greek Orthodox Priest\'s Experience in a Medical Laboratory [PDF]

, 2012
The author describes his experience as a Greek Orthodox priest working in the field of medicine. While in medical school, the author had the opportunity To work in a laboratory that sought to provide to government authorities the results of genetic ...
Griniezakis, Makarios
core   +1 more source

Cysticercosis and taeniasis cases diagnosed at two referral medical institutions, Belgium, 1990 to 2015 [PDF]

, 2019
Background: Few case reports on human infections with the beef tapeworm Taenia saginata and the pork tapeworm, Taenia solium, diagnosed in Belgium have been published, yet the grey literature suggests a higher number of cases.
Bottieau, Emmanuel, Dermauw, Veronique, Dorny, Pierre, Luyckx, Kim, Luyten, Leon, Van Bockstal, Lieselotte, Van Den Broucke, Steven   +6 more
core   +1 more source

Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle, Kiersten Ricci, Kelly Blache, Rebecca A. Marsh, Adrienne M. Hammill, Elissa Engel   +5 more
wiley   +1 more source

Factors affecting the number of nonconformities from the assessment of safety in medical laboratory according to ISO 15190:2003

Journal of Associated Medical Sciences, 2016
Background: Bureau of Laboratory Quality Standards established medical laboratory safety accreditation program according to ISO 15190: 2003 in Thailand since May 2013. Nonconformities (NCs) were found from 1 to 18 in each laboratory. Number of NCs may be
Surasak Muenphon, Panadda Wiroonboonpat, Sirimart Kumsai, Maliwan Homchan, Aekkarin Submark, Prompussorn Dissara, Natamol Tianmanee, Dhitiwass Suvagandha, Suthon Vongsheree   +8 more
doaj  

Aligning Pathology Assessment in a Learner-Centered Undergraduate Medical Curriculum [PDF]

, 2017
Introduction: The Bond Medical Program delivers pathology in the preclinical years through interactive learning. Assessment for learning demands fit-for-purpose assessment that aligns with the curriculum.
Doshi, Neelam, Tepper, Carmel, Wright, Robert Gordon   +2 more
core   +1 more source

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source