Results 61 to 70 of about 2,959,314 (265)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Modeling geographical accessibility to medical laboratory services in Iran: methodology and its challenges

Payesh, 2015
Objectives: Recent advances in health geography helped to understand more on the role of the geographical distribution and settings of diagnostic and therapeutic centers in the communities.
Jila Sadighi, Ali Hosseini, Kazem Mohammad, Saeed Mahdavi, Siamak Mirab Samiee, Nooshafarin Safadel, Vahid Banaei, Katayoun Jahangiri, Rahele Rostami   +8 more
doaj  

Responding to the needs of medical laboratory professionals: The CSMLS Mental Health Toolkit

Journal of Community Safety and Well-Being
Canadian Society for Medical Laboratory Science (CSMLS) is Canada’s national certifying body and professional society for medical laboratory professionals. Their research revealed increasing levels of workplace stress among their membership and concerns
Rosina Mete, Brandon Djukic, Christine Nielsen   +2 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Medical law: Exploring doctors' knowledge on the laws regulating clinical and medical laboratories in Nigeria.

Nigerian Journal of Medicine, 2019
BACKGROUND The Nigerian healthcare system has experienced repeated disharmony between the Medical Laboratory Scientist and the Pathologist. This may be seemingly due to lack of understanding of the Medical Laboratory Science Council of Nigeria (MLSCN ...
F Archibong, A Atangwho, A E Ayuk, I E Okoye, M Atrogor, I B Okokon   +5 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Assessment of the Impact of Smart Refrigerators on the Preanalytical Phase to Enhance the Transport and Storage of Blood Samples in Primary Care

NSC Nursing
Introduction: This study investigates the impact of smart refrigerators on the logistics and management of biological samples, emphasizing the critical phases of transport and storage to enhance the pre-analytical quality of blood samples.
Vidal Navarro Ana , Férriz Tena Náyades , Carreres Giménez María Encarnación , Verdu Quirant Trinidad , Menchón Simón María de las Nieves , Campello García María José , Serrano López Juan Francisco , Soler Climent Esther   +7 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source