Results 101 to 110 of about 2,333,563 (341)

The Rewiring of Ubiquitination Targets in a Pathogenic Yeast Promotes Metabolic Flexibility, Host Colonization and Virulence [PDF]

, 2016
Funding: This work was funded by the European Research Council [http://erc.europa.eu/], AJPB (STRIFE Advanced Grant; C-2009-AdG-249793). The work was also supported by: the Wellcome Trust [www.wellcome.ac.uk], AJPB (080088, 097377); the UK Biotechnology ...
A Brand, A Enache-Angoulvant, A Rodaki, A Rosenbach, AJP Brown, AJP Brown, AL Diaz-Perez, Alistair J. P. Brown, AM New, B Gorke, C Fradin, C Janke, C Taxis, CJ Barelle, CR Rocha, D Lohr, D Sandai, DA Opulente, David Stead, Delma S. Childers, DH Owen, DM MacCallum, Donna M. MacCallum, DS Childers, EJ Munoz-Elias, Elizabeth R. Ballou, F Cao, F Sherman, FC Odds, Gabriela Mol Avelar, H Holzer, H Zhou, HG Crabtree, HL Cheah, Ingrida Raziunaite, IV Ene, IV Ene, J Piskur, J Regelmann, J Shen, JA Sexton, JH Hegemann, JK Byron, JM Gancedo, Joanna Mackie, JP Barford, K Piekarska, K Ueno, M Carlson, M Hammerle, M Johnston, M Niimi, MA Navas, MA Ramirez, MC Lorenz, MC Lorenz, Megan D. Lenardon, MS Price, Neil A. R. Gow, O Santt, P Miramon, P Radivojac, PL Fidel Jr., R Menssen, R Sabouraud, R Sharma, RA Calderone, RA Calderone, Robert A. Cramer, S Funayama, Susan Budge, T Inada, T Schule, TH Rude, YS Lopez-Boado, Z Yin   +75 more
core   +4 more sources

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Intestinal Parasitic Infections Among Patients Who Visited Woldia Comprehensive Specialized Hospital’s Emergency Department Over a Six-Year Period, Woldia, Ethiopia: A Retrospective Study

Infection and Drug Resistance, 2022
Solomon Rega,1 Yimer Melese,2 Alene Geteneh,3 Desie Kasew,4 Tegegne Eshetu,5 Sirak Biset4 1Department of Medical Laboratory Science, Woldia Comprehensive Specialized Hospital, Woldia, Ethiopia; 2Department of Medical Laboratory Science, Dessie Health ...
Rega S, Melese Y, Geteneh A, Kasew D, Eshetu T, Biset S   +5 more
doaj  

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Relevant research areas for biomedical laboratory scientists in medical biochemistry

Bioingeniøren, 2018
Introduction. Biomedical laboratory science is a somewhat invisible profession. To identify research areas within biomedical laboratory science, could contribute to make the profession more visible.
Synnøve Hofseth Almås, Ragnhild Nilsen
doaj  

TRIM55 Promotes Proliferation of Hepatocellular Carcinoma Through Stabilizing TRIP6 to Activate Wnt/β-Catenin Signaling

Journal of Hepatocellular Carcinoma, 2023
Xun Lu,1– 3 Yue Yuan,4 Ning Cai,1– 3 Dean Rao,1– 3 Min Chen,4 Xiaoping Chen,1– 3 Bixiang Zhang,1– 3 Huifang Liang,1– 3 Lei Zhang3,5 1Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan ...
Lu X, Yuan Y, Cai N, Rao D, Chen M, Chen X, Zhang B, Liang H, Zhang L   +8 more
doaj  

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

More Than Half Prevalence of Protozoan Parasitic Infections Among Diarrheic Outpatients in Eastern Tigrai, Ethiopia, 2019; A Cross-Sectional Study

Infection and Drug Resistance, 2020
Brhane Berhe,1 Fitsum Mardu,1 Kebede Tesfay,1 Haftom Legese,2 Gebre Adhanom,2 Hagos Haileslasie,3 Gebremedhin Gebremichail,3 Brhane Tesfanchal,4 Niguse Shishay,5 Hadush Negash2 1Unite of Medical Parasitology and Entomology, Department of Medical ...
Berhe B, Mardu F, Tesfay K, Legese H, Adhanom G, Haileslasie H, Gebremichail G, Tesfanchal B, Shishay N, Negash H   +9 more
doaj  

Helicobacter pylori Pathogenicity Islands and Giardia lamblia Cysteine Proteases in Role of Coinfection and Pathogenesis

Infection and Drug Resistance, 2022
Mihret Tilahun,1 Alemu Gedefie,1 Chernet Belayhun,2 Zenawork Sahle,3 Admasu Abera3 1Department of Medical Laboratory Sciences, College of Medicine and Health Science, Wollo University, Dessie, Ethiopia; 2Department of Medical Laboratory Science, Mehal ...
Tilahun M, Gedefie A, Belayhun C, Sahle Z, Abera A   +4 more
doaj  

Factors Affecting Resilience of Nursing, Optometry, Radiography and Medical Laboratory Science Students. [PDF]

Int J Environ Res Public Health, 2021
Ching SSY, Cheung K.
europepmc   +1 more source