Results 81 to 90 of about 1,403,791 (257)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Relevance of Artificial Intelligence in Medical Laboratory Science with Emphasis on Histopathology Specialty.

Sokoto Journal of Medical Laboratory Science, 2019
The act of creating machines that carry out functions requiring intelligence performed by humans is often known as artificial intelligence (AI). When the act is replicated in Medicine and especially in the current day histopathology practice, then it is ...
Odigie, B.E. 1 and Abude, C.V.
doaj  

34th Malaysian Association of Clinical Biochemists Annual Conference in collaboration with 2nd Malaysian Biomedical Science Association Symposium 2024

Life Sciences, Medicine and Biomedicine
The Malaysian Association of Clinical Biochemists (MACB) and the Malaysian Biomedical Science Association (MyBiomed) successfully organized the 34th MACB Conference in conjunction with the 2nd MyBiomed Symposium 2024.
Wan Amir Nizam Wan Ahmad, Seri Narti Edayu Sarchio, Nur Najmi Mohamad Anuar, Nor Fadilah Rajab, Suvik Assaw, Rhun Yian Koh, Chooi Ling Lim, Nur Aishah Sharudin, Norlida Harun, Nurulamin Abu Bakar, Mohd Arifin Kaderi   +10 more
doaj   +1 more source

High Prevalence of Multi-Drug Resistance and Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae Among Hospitalized Patients Presumptive for Bacterial Infection at Debre Berhan Comprehensive Specialized Hospital, Ethiopia

Infection and Drug Resistance, 2022
Zenawork Sahle,1 Getabalew Engidaye,1 Demissew Shenkute,2 Yeshi Metaferia,3 Agumas Shibabaw3 1Department of Medical Laboratory Science, Debre Berhan Health Science College, Debre Berhan, Ethiopia; 2Department of Medical Laboratory Science, College of ...
Sahle Z, Engidaye G, Shenkute D, Metaferia Y, Shibabaw A   +4 more
doaj  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Responding to the needs of medical laboratory professionals: The CSMLS Mental Health Toolkit

Journal of Community Safety and Well-Being
Canadian Society for Medical Laboratory Science (CSMLS) is Canada’s national certifying body and professional society for medical laboratory professionals. Their research revealed increasing levels of workplace stress among their membership and concerns
Rosina Mete, Brandon Djukic, Christine Nielsen   +2 more
doaj   +1 more source

Bacterial and Fungal Profile, Antibiotic Susceptibility Patterns of Bacterial Pathogens and Associated Risk Factors of Urinary Tract Infection Among Symptomatic Pediatrics Patients Attending St. Paul’s Hospital Millennium Medical College: A Cross-Sectional Study [Response to Letter]

Infection and Drug Resistance, 2022
Adane Bitew,1 Nuhamen Zena,2 Abera Abdeta3 1Department of Medical Laboratory Science, College Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia; 2Department of Microbiology, St Paul Hospital Millennium Medical College, Addis Ababa, Ethiopia;
Bitew A, Zena N, Abdeta A
doaj  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source