Results 121 to 130 of about 3,008,227 (355)

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

Human Health: Medical Scientific Principles to Increase IT [PDF]

, 1998
To solve the present health scientific problems, requires a synthesis of the theoretical results of the analytic and reductive research made by the laboratory, clinical and public health, medical sciences.
Stusser, R. J. (Rudolf)
core  

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Relevant research areas for biomedical laboratory scientists in medical biochemistry

Bioingeniøren, 2018
Introduction. Biomedical laboratory science is a somewhat invisible profession. To identify research areas within biomedical laboratory science, could contribute to make the profession more visible.
Synnøve Hofseth Almås, Ragnhild Nilsen
doaj  

More Than Half Prevalence of Protozoan Parasitic Infections Among Diarrheic Outpatients in Eastern Tigrai, Ethiopia, 2019; A Cross-Sectional Study

Infection and Drug Resistance, 2020
Brhane Berhe,1 Fitsum Mardu,1 Kebede Tesfay,1 Haftom Legese,2 Gebre Adhanom,2 Hagos Haileslasie,3 Gebremedhin Gebremichail,3 Brhane Tesfanchal,4 Niguse Shishay,5 Hadush Negash2 1Unite of Medical Parasitology and Entomology, Department of Medical ...
Berhe B, Mardu F, Tesfay K, Legese H, Adhanom G, Haileslasie H, Gebremichail G, Tesfanchal B, Shishay N, Negash H   +9 more
doaj  

High Magnitude of Fecal Carriage of Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae at Debre Berhan Comprehensive Specialized Hospital, Ethiopia

Infection and Drug Resistance, 2022
Demissew Shenkute,1 Melese Hailu Legese,2 Berhanu Yitayew,1 Asaye Mitiku,3 Getabalew Engidaye,4 Saba Gebremichael,5 Daniel Asrat,6 Yimtubezinash Woldeamanuel6 1Department of Medical Laboratory Science, College of Health Sciences, Debre Berhan University,
Shenkute D, Legese MH, Yitayew B, Mitiku A, Engidaye G, Gebremichael S, Asrat D, Woldeamanuel Y   +7 more
doaj  

Medical Laboratory Science: The cornerstone of contemporary medicine

Modern medicine is built on the basis of medical laboratory science, which performs a wide range of crucial tasks that support illness detection, treatment, prevention, and research. Its impact on clinical decision-making, public health policy, and the advancement of medical knowledge reaches well beyond the confines of the laboratory.
Nsonwu C. C, Johnkennedy N, Nnodim P. A
openaire   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Helicobacter pylori Pathogenicity Islands and Giardia lamblia Cysteine Proteases in Role of Coinfection and Pathogenesis

Infection and Drug Resistance, 2022
Mihret Tilahun,1 Alemu Gedefie,1 Chernet Belayhun,2 Zenawork Sahle,3 Admasu Abera3 1Department of Medical Laboratory Sciences, College of Medicine and Health Science, Wollo University, Dessie, Ethiopia; 2Department of Medical Laboratory Science, Mehal ...
Tilahun M, Gedefie A, Belayhun C, Sahle Z, Abera A   +4 more
doaj  

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source