Results 81 to 90 of about 3,008,227 (355)

Message from the Director Institute of Health Care [PDF]

, 2005
Fifteen years have passed since the Institute of Health Care was founded within the University of Malta. In line with advances in health care professional education worldwide, and indeed with advances in medical knowledge, technology, health service ...
Buttigieg, Sandra C.
core  

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Red Blood Cell Distribution Width as a Biomarker in Type 2 Diabetes Mellitus: Technical Notes [Response to Letter]

Diabetes, Metabolic Syndrome and Obesity, 2023
Mesay Arkew,1 Haftu Asmerom,1 Tewodros Tesfa,1 Setegn Tsegaye,2 Kabtamu Gemechu,1 Tilahun Bete,3 Kassahun Haile4 1School of Medical Laboratory Sciences, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia; 2College of Health and ...
Arkew M, Asmerom H, Tesfa T, Tsegaye S, Gemechu K, Bete T, Haile K   +6 more
doaj  

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

Ethics, space, and somatic sensibilities: comparing relationships between scientific researchers and their human and animal experimental subjects [PDF]

, 2011
Drawing on geographies of affect and nature-society relations, we propose a radical rethinking of how scientists, social scientists, and regulatory agencies conceptualise human and animal participants in scientif ic research. The scientific rationale for
Birke L, Boo M J, Buchanan-Smith H M, Butler R, Calarco M, Ehni H, FAWC, Fenwick N P, Grandin T, Grosz E, Haraway D, Harlow H, Hinchliffe S, Jones O, Katz J, Keller E F, Latour B, Lawler J, Leach M, Lorimer J, Nast H J, Paterson M, RCN, RCN, Roe E, Rudge T, Russell W M S, Singer P, Stengers I, Thrift N, Vorstenbosch J M C, Wemelsfelder F, Whatmore S, Wolfe C   +33 more
core   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Knowledge and Awareness of Histopathology Specialty by Medical Laboratory Science Undergraduate Students in Edo State

Sokoto Journal of Medical Laboratory Science, 2017
Over the years histopathology specialty has received a lesser number of students specializing in the area according to statistics. For this reason, we investigated the knowledge and awareness of histopathology specialty amongst Medical Laboratory Science
Odigie, B.E., Erameh, T.O.
doaj  

Green is the Colour: St. Petersburg's Chemical Laboratories and Competing Visions of Chemistry in the Eighteenth Century [PDF]

, 2013
Histories of chemistry in eighteenth-century Russia have often ignored or downplayed the scientific character of chemical sites, treating the chemical laboratory of M.V. Lomonosov in St. Petersburg's Imperial Academy of Sciences as the definitive site of
Werrett, S
core   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Current Review on Infamous Practices in Medical Laboratory Science Profession

Sokoto Journal of Medical Laboratory Science, 2017
Th term infamous is well known for some bad quality or deeds. Wicked, abominable, outrageous, disreputable, ill-fame, discreditable, shameful, dishonorable, scandalous, heinous, vile and unspeakable.
Omorodion, N.T.*, Achukwu, P.U., Umeh, G.U., Igharo, E.A.
doaj