Results 81 to 90 of about 2,058,657 (343)

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

Molecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Elin Borgen, Cecilie Bendigtsen Schirmer, Bjørnar Gilje, Øystein Garred, Jon Lømo, Marius Stensland, Oddmund Nordgård, Ragnhild Sørum Falk, Randi R. Mathiesen, Hege G. Russnes, Jon Amund Kyte, Bjørn Naume   +13 more
wiley   +1 more source

Observational Assessment of Pre-Analytical Errors in Request Format and Phlebotomy Practice in Hematology Tests at Hawassa University Comprehensive Specialized Hospital in Sidama Zone, Southern Ethiopia

Pathology and Laboratory Medicine International, 2023
Bedasa Addisu,1 Amanuel Kelem,2 Agete Tadewos Hirigo3 1Department of Medical Laboratory Science, College of Medicine and Health Sciences, Debre Berhan University, Debre Berhan, Amhara, Ethiopia; 2Department of Medical Laboratory Sciences, Asrat Woldeyes ...
Addisu B, Kelem A, Hirigo AT
doaj  

A new definition of the fractional Laplacian [PDF]

arXiv, 2002
It is noted that the standard definition of the fractional Laplacian leads to a hyper-singular convolution integral and is also obscure about how to implement the boundary conditions. This purpose of this note is to introduce a new definition of the fractional Laplacian to overcome these major drawbacks.
arxiv  

A Flexible Positron Spectrometer for the Undergraduate Laboratory [PDF]

, 2017
Positron physics touches on a wide-ranging variety of fields from materials science to medical imaging to high energy physics. In this paper we present the development of a flexible positron annihilation spectrometer appropriate for the undergraduate laboratory.
arxiv   +1 more source

A Comprehensive Study on Machine Learning Methods to Increase the Prediction Accuracy of Classifiers and Reduce the Number of Medical Tests Required to Diagnose Alzheimer'S Disease [PDF]

arXiv, 2022
Alzheimer's patients gradually lose their ability to think, behave, and interact with others. Medical history, laboratory tests, daily activities, and personality changes can all be used to diagnose the disorder. A series of time-consuming and expensive tests are used to diagnose the illness.
arxiv  

A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells were spiked into donor blood to evaluate the recovery rates of the following circulating tumor cell (CTC) enrichment technologies: CellMag™, EasySep™, RosetteSep™, Parsortix® PR1, and Parsortix® Prototype systems. Each method's advantages and disadvantages are described.
Volga M Saini, Ezgi Oner, Mark P. Ward, Sinead Hurley, Brian David Henderson, Faye Lewis, Stephen P. Finn, Gerard J. Fitzmaurice, John J. O'Leary, Sharon O'Toole, Lorraine O'Driscoll, Kathy Gately   +11 more
wiley   +1 more source

A Reply to the Letter in Response to the Article “Seroprevalence of Hepatitis B Virus, Hepatitis C Virus, Syphilis, and Associated Factors Among Female Sex Workers in Gondar Town, Northwest Ethiopia” [Response to Letter]

Infection and Drug Resistance, 2022
Mitikie Wondmagegn,1,* Yitayih Wondimeneh,2 Alem Getaneh,2 Getnet Ayalew2,* 1Department of Medical Laboratory Science, College of Medicine and Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia; 2Department of Medical Microbiology ...
Wondmagegn M, Wondimeneh Y, Getaneh A, Ayalew G   +3 more
doaj  

X-ray imaging detector for radiological applications in the harsh environments of low-income countries [PDF]

arXiv, 2020
This paper describes the development of a novel medical Xray imaging system adapted to the needs and constraints of low and middle income countries. The developed system is based on an indirect conversion chain: a scintillator plate produces visible light when excited by the Xrays, then a calibrated multi camera architecture converts the visible light ...
arxiv  

KRAS and GNAS mutations in cell‐free DNA and in circulating epithelial cells in patients with intraductal papillary mucinous neoplasms—an observational pilot study

Molecular Oncology, EarlyView.
This study demonstrates that KRAS and GNAS mutations are more prevalent in patients with resected intraductal papillary mucinous neoplasms (IPMN) compared to those under clinical surveillance. GNAS mutations significantly differ between the two patient cohorts, indicating that their absence may serve as a potential biomarker to support conservative ...
Christine Nitschke, Marie Tölle, Philipp Walter, Kira Meißner, Mara Goetz, Jolanthe Kropidlowski, Andreas W. Berger, Jakob R. Izbicki, Felix Nickel, Thilo Hackert, Klaus Pantel, Harriet Wikman, Faik G. Uzunoglu   +12 more
wiley   +1 more source