Results 101 to 110 of about 5,910,455 (386)

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu   +11 more
wiley   +1 more source

It's About Time: Learning Time and Educational Opportunity in California High Schools [PDF]

open access: yes, 2014
A new study by the UCLA Institute for Democracy, Education and Access (IDEA) found that teachers in high-poverty schools are more likely than their peers in low-poverty schools to report more time lost for academic instruction due to poor access to ...
John Rogers, Nicole Mirra
core  

About the MeSH information and retrieval query language in the area of activity of Polish academic libraries of medical universities

open access: yesForum Bibliotek Medycznych
The article presents the history of MeSH, the information and retrieval query language in Poland, in the context of cooperation between academic medical libraries. It also discusses the role of the Central Medical Library in the implementation of medical
Magdalena Kotlarek-Naskręt
doaj   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

Promoting Improved Access to Consumer Health Information [PDF]

open access: yes, 2005
“Do you have any information on lupus?” “What are the side effects of Prozac?” “I want to find an herbal remedy for arthritis.” Questions such as these are asked each day across the country at public library reference desks.
Kaiser, Josephine
core  

AGMB-Arbeitskreis österreichischer Medizinbibliothekarinnen und -bibliothekare (AGMB.AT): Bericht vom 8. Treffen 2018 und vom 9. Treffen 2019

open access: yesGMS Medizin – Bibliothek – Information, 2019
The work group Austrian Medical Librarians (AGMB.AT) is a platform for the exchange of information and experience amongst medical librarians. On Dec 12, 2018 the 8 meeting took place at the Medical University Vienna.
Bauer, Bruno   +2 more
doaj   +1 more source

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

open access: yesMolecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

GPU cards as a low cost solution for efficient and fast classification of high dimensional gene expression datasets [PDF]

open access: yes, 2010
The days when bioinformatics tools will be so reliable to become a standard aid in routine clinical diagnostics are getting very close. However, it is important to remember that the more complex and advanced bioinformatics tools become, the more ...
Benso, Alfredo   +4 more
core  

Librarians use of Web 2.0 in UK Medical Schools: Outcomes of a national survey [PDF]

open access: yes, 2010
Using the results of an Email survey, this paper reviews the use of Web 2.0 technologies by librarians working in UK Medical Schools. Web 2.0 has been hailed as an innovation for facilitation of two way communication on the net, and it is, therefore ...
Grant, V, Kuhn, I, Pacheco, J
core   +1 more source

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