Results 71 to 80 of about 9,094,335 (302)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A Research on Tabriz University of Medical Sciences Libraries Staff, Collection, Space and Budget Comparison with Iranian University Libraries Standards

مدیریت اطلاعات سلامت, 2010
Introduction: Academic libraries are famous to be the hearts of universities, with the ever increasing importance of the evaluation of information technologies in academic centers, and libraries need to evaluate their status to accord with these ...
Kamal Ebrahimi, Shafi Habibi, Gholamhossein Tasbihi   +2 more
doaj  

Ergebnisse einer Umfrage unter Medizinbibliotheken im deutschsprachigen Raum 2017

GMS Medizin – Bibliothek – Information, 2018
On behalf of the AGMB section for medical libraries at universities, an online survey was realized among medical libraries at universities in summer 2017.
Weiner, Oliver, Wibker, Katrin
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Elektronik Sağlık Kayıt Sistemlerinin Kütüphanelerle Bütünleştirilmesi / Integrating Libraries to Electronic Health Record Systems

Bilgi Dünyası, 2005
The increase of volume and variety of information, which in turn has an important role in health services, reached to an explosive bulk, that can hardly be managable for the users.
Ayşen Küyük, Aslan Kaplan, Ali Yılmaz   +2 more
doaj  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Assessment of the effectiveness of medical simulators in the practical training of medical students: Preliminary results in MU-Varna [PDF]

, 2019
INTRODUCTION: Nowadays, simulators have become part of most medical universities’ educational strategy. In recent years, Medical University of Varna has been equipped with the most modern medical simulators, aiming to meet the practical training needs of
Chernogorova, Yanita; Medical University of Varna, Grancharov, Deyan; Medical University of Varna, Bliznakov, Zhivko; Medical University of Varna   +2 more
core   +7 more sources

AGMB-Wettbewerb „Leuchtturmprojekte an Medizinbibliotheken 2020“: Würdigung der Preisträger

GMS Medizin – Bibliothek – Information, 2020
The projects of the winners of the competition “Pioneer projects in medical libraries 2020” are introduced and the statement of the jury explained.
Reimann, Iris
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Medical libraries: open and innovative by tradition

, 2018
The focus of the current issue 3/2018 of GMS Medizin - Bibliothek - Information is on the annual conference 2018 of the German Medical Libraries Association in Oldenburg.
Bauer, B
core   +1 more source