Results 281 to 290 of about 751,918 (339)

Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting

Advanced Materials, EarlyView.
CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu, Won Joon Kim, Hyunjin Lee, Xiaoping Bao, Pilnam Kim   +4 more
wiley   +1 more source

Off‐The‐Shelf Multivalent Nanoconjugate Cancer Vaccine Rescues Host Immune Response against Melanoma

Advanced Materials, EarlyView.
A star‐shaped cross‐linked polyglutamate (StCl) nanocarrier delivers melanoma‐associated peptide antigens via redox‐responsive linkers, inducing lymph node‐targeted antigen presentation. The nanoconjugate activates dendritic cells, promotes effector T‐cell responses, and enables tumor regression even in humanized patient‐derived preclinical models ...
Liane IF Moura, Alessio Malfanti, Ana I Matos, Carina Peres, Ana Armiñán, Aroa Duro‐Castaño, Inmaculada Conejos‐Sánchez, María Medel, Snežana Đorđević, Paula Carrascosa, Bárbara Carreira, Rita C Acúrcio, Helena Xavier‐Ferreira, Alberto Hernández‐Barranco, Elena Castellano, Esther Roselló, José C. Machado, Héctor Peinado, María J. Vicent, Helena F. Florindo   +19 more
wiley   +1 more source

Formulation and Characterization of Novel Ionizable and Cationic Lipid Nanoparticles for the Delivery of Splice‐Switching Oligonucleotides

Advanced Materials, EarlyView.
Lipid nanoparticles (LNPs) of unconventional composition and defined structures are investigated as small oligonucleotide carriers. A composition is identified that outperforms Onpattro in cargo delivery to HeLa cells. The structure of these LNPs resembles a micellar cubic phase not commonly associated with high‐performing LNPs.
Miina Ojansivu, Hanna M. G. Barriga, Margaret N. Holme, Stefanie Morf, James J. Doutch, Samir EL Andaloussi, Tomas Kjellman, Markus Johnsson, Justas Barauskas, Molly M. Stevens   +9 more
wiley   +1 more source

Two Material Properties from One Wavelength‐Orthogonal Photoresin Enabled by a Monochromatic Laser Integrated Stereolithographic Apparatus (Mono LISA)

Advanced Materials, Volume 37, Issue 13, April 2, 2025.
A single object with dual properties – degradable and non‐degradable – is fabricated in a single print simply by switching the printing colors. The advanced multi‐material printing is enabled by the combination of a fully wavelength‐orthogonal photoresin and a monochromatic tunable laser printer, paving the way for precise multi‐material ...
Xingyu Wu, Katharina Ehrmann, Ching Thye Gan, Benjamin Leuschel, Fred Pashley‐Johnson, Christopher Barner‐Kowollik   +5 more
wiley   +1 more source

Unlocking Multimodal Nonlinear Microscopy for Deep‐Tissue Imaging under Continuous‐Wave Excitation with Tunable Upconverting Nanoparticles

Advanced Materials, EarlyView.
This study introduces a multimodal nonlinear microscopy approach using upconverting nanoparticles (UCNPs) under continuous‐wave excitation. The UCNPs exhibit high‐order nonlinear optical responses, enabling deep‐tissue 3D imaging, video‐rate wide‐field imaging, and depth‐selective photomodulation.
Jeongmo Kim, Seunghun Lee, Yundon Jeong, Kyunghwan Kim, Kibum Nam, Hyungwon Jin, Yuha Choi, Hyun‐Jin Kim, Heungjin Ryu, Ki Hean Kim, Jae‐Ick Kim, Jongnam Park, Jinmyoung Joo, Jung‐Hoon Park   +13 more
wiley   +1 more source

Medical Libraries in Hospitals.

Medical library and historical journal, 1998
openaire   +3 more sources