Results 51 to 60 of about 761,130 (313)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Der Webauftritt – eine Dauerbaustelle / The website – constantly under construction

open access: yesGMS Medizin – Bibliothek – Information, 2010
Three web projects for the site http://www.ma.uni-heidelberg.de/bibl/ of the Library of the Medical Faculty of Mannheim are shown from the webteam’s perspective – from the first brainstorming sessions to the final design: relaunch, translation, usability-
Boeckh, Dorothee
doaj  

AGMB 2020: Innovativ in die nächsten 50 Jahre

open access: yesGMS Medizin – Bibliothek – Information, 2020
The unexpected death of the longtime editor-in-chief of this journal overshadows the current issue, which is otherwise all about the AGMB annual conference 2020. In addition to the obituary for Mr.
Dollfuß, Helmut
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Medizinbibliothekarische Bibliografie 2011 [The Medical Librarian’s Bibliography 2011]

open access: yesGMS Medizin – Bibliothek – Information, 2012
[english] The Medical Librarian’s Bibliography 2011 lists all articles from and selected publications relevant to medical librarians from following journals: [german] In der Medizinbibliothekarischen Bibliografie 2011 sind sämtliche Beiträge von sowie ...
Bauer, Bruno
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

MEDICAL LIBRARIES [PDF]

open access: yesJournal of the American Medical Association, 1909
One of the serious problems which confronts the management of every library is the proper and equable apportioning of the book fund to the several departments. The problem is, of necessity, a flexible one and varies with the environment, the resources and the policy of the individual library.
openaire   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui   +6 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

Medizinbibliothekarische Bibliographie 2007 / The Medical Librarian's Bibliography 2007

open access: yesGMS Medizin – Bibliothek – Information, 2008
The Medical Librarian’s Bibliography 2007 lists all articles from GMS Medizin – Bibliothek – Information and selected publications relevant to medical librarians from following journals: ABI Technik, Bibliothek Forschung und Praxis, Bibliotheksdienst ...
Bauer, Bruno
doaj  

Home - About - Disclaimer - Privacy