Results 51 to 60 of about 2,133,151 (312)

Evidenzbasierte Medizin – Chance für Medizinbibliotheken

GMS Medizin – Bibliothek – Information, 2020
The focus of the current issue 1-2/2020 of GMS MEDIZIN – BIBLIOTHEK – INFORMATION is on evidence-based medicine and systematic review in German, Austrian and Swiss medical libraries.
Buroh, Sabine, Cascant Ortolano, Lorena, Schweizer, Stefanus   +2 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Filiale im Feld – Die Zweigstelle für Medizin und Naturwissenschaften der Universitätsbibliothek Heidelberg / Neuenheim Branch Library of Medicine and Natural Sciences, University Library of Heidelberg

GMS Medizin – Bibliothek – Information, 2009
The Neuenheim Branch Library of Medicine and Natural Sciences of the University Library of Heidelberg was founded in 1978 and is responsible for the literature and information supply of about 11.000 students and more than 5000 scientists and physicians ...
Mauthe, Sybille
doaj  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Leuchtturmprojekte an Medizinbibliotheken: „Systematische Literaturrecherche an der Bibliothek der Medizinischen Fakultät Mannheim der Universität Heidelberg“

GMS Medizin – Bibliothek – Information, 2013
[english] In the past years, the Library for the Medical Faculty of Mannheim of the University of Heidelberg has been confronted with an increased demand for extensive advice on complex literature searches.
Metzendorf, Maria-Inti
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Status of the Cybernetic Model Components in the Libraries of Iran's Type 1 Medical Sciences Universities [PDF]

بازیابی دانش و نظام‌های معنایی
IntroductionCybernetics, a science that emerged in the 20th century, has rapidly grown and penetrated various disciplines. Since its inception, cybernetics has experienced significant and continuous growth, with communication and the concepts of message ...
Fereshteh Bayanlou, Zohreh Mirhosseini, Zahra Abazari   +2 more
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

AGMB 2020: Innovativ in die nächsten 50 Jahre

GMS Medizin – Bibliothek – Information, 2020
The unexpected death of the longtime editor-in-chief of this journal overshadows the current issue, which is otherwise all about the AGMB annual conference 2020. In addition to the obituary for Mr.
Dollfuß, Helmut
doaj   +1 more source