Results 51 to 60 of about 7,482,890 (301)

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

open access: yesMolecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti   +10 more
wiley   +1 more source

ZB MED – Informationszentrum Lebenswissenschaften: 10 Fragen von Bruno Bauer an dessen Direktor Dietrich Rebholz-Schuhmann

open access: yesGMS Medizin – Bibliothek – Information, 2019
Since 2018 Dietrich Rebholz-Schuhmann is scientific director of – Information Centre for Life Sciences. In this interview he speaks on his motivation for assuming that task and informs about his aims. By intensifying ZB MED’s research activities, the re-
Bauer, Bruno   +1 more
doaj   +1 more source

Evidenzbasierte Medizin – Chance für Medizinbibliotheken

open access: yesGMS Medizin – Bibliothek – Information, 2020
The focus of the current issue 1-2/2020 of GMS MEDIZIN – BIBLIOTHEK – INFORMATION is on evidence-based medicine and systematic review in German, Austrian and Swiss medical libraries.
Buroh, Sabine   +2 more
doaj   +1 more source

The new Medical Library Association research agenda: final results from a three-phase Delphi study.

open access: yesJournal of the Medical Library Association, 2012
The Medical Library Association’s (MLA’s) 2007 research policy statement [1] charged the MLA Research Section with defining the MLA research agenda on a recurring basis [2].
J. Eldredge   +3 more
semanticscholar   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

Medizinbibliotheken heute. Orte im digitalen Wandel

open access: yesGMS Medizin – Bibliothek – Information, 2016
The focus of the current issue 3/2016 of GMS Medizin – Bibliothek – Information is on the annual conference 2016 of the German Medical Libraries Association in Göttingen. The motto of the conference was “Medical libraries today.
Bauer, Bruno
doaj   +1 more source

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

open access: yesMolecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla   +5 more
wiley   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

Durch Kooperation und Vernetzung zu neuen Aufgabenfeldern – Serviceentwicklung in der Bibliothek der Medizinischen Fakultät Mannheim [Opening up new tasks through cooperation and networking – service development in the Library for the Medical Faculty of Mannheim]

open access: yesGMS Medizin – Bibliothek – Information, 2013
[english] The Library for the Medical Faculty of Mannheim of the University of Heidelberg supplies literature and information for research, teaching and further education purposes at the “Universitätsmedizin Mannheim”. Cooperation and networking with the
Semmler-Schmetz, Martina   +1 more
doaj   +1 more source

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

open access: yesMolecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh   +8 more
wiley   +1 more source

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