Results 71 to 80 of about 746,927 (314)

10 Fragen von Bruno Bauer an Dietrich Nelle, den Interimsdirektor von ZB MED – Informationszentrum Lebenswissenschaften

open access: yesGMS Medizin – Bibliothek – Information, 2018
ZB MED – Information Center for Life Sciences is the largest library worldwide in the field of life sciences. From October 2016 to June 2018 Dietrich Nelle was its interim managing director.
Bauer, Bruno, Nelle, Dietrich
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Library of the Medical University of Silesia in Katowice for the European City of Science – report, summary

open access: yesForum Bibliotek Medycznych
The article presents how the Library of the Medical University of Silesia in Katowice was involved in the European City of Science Katowice 2024 project, with emphasis on the 50 Weeks in the City of Science cycle.
Katarzyna Cukierska   +1 more
doaj   +1 more source

Medizinbibliothekarische Bibliografie 2017

open access: yesGMS Medizin – Bibliothek – Information, 2018
The Medical Librarian’s Bibliography 2017 lists all articles from GMS Medizin – Bibliothek – Information and selected publications relevant to medical librarians from following journals: ABI Technik, Bibliothek Forschung und Praxis, Bibliotheksdienst, B ...
Bauer, Bruno
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Die Fachbibliothek Medizin an der Johannes-Gutenberg-Universität Mainz / The Medical Branch Library at the Johannes-Gutenberg-University Mainz

open access: yesGMS Medizin – Bibliothek – Information, 2009
The Medical Library (Fachbibliothek Medizin (FBM)) was founded in 1969 as a Department of the Central University Library (Zentralbibliothek), and is located within the grounds of the University Medical Center in Mainz.
Geisel, Heike, Schweizer, Stefanus
doaj  

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

open access: yesFEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho   +4 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

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