Results 81 to 90 of about 35,024,832 (231)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Correction to “Performance of a mixed filter to identify relevant studies for mixed studies reviews” on page 49, 104(1) January 2016. DOI: http://dx.doi.org/10.5195/jmla.2018.214

open access: yesJournal of the Medical Library Association, 2019
Corrects Table 1 and total number of records identified in the study of “Performance of a mixed filter to identify relevant studies for mixed studies reviews” on page 49, 104(1) January 2016. DOI: http://dx.doi.org/10.5195/jmla.2018.214.
Katherine G. Akers
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Compensation Guidelines for Kansas Public Library Directors, 2003

open access: yes, 2003
Cover title.; "This publication was written by the KLA Public Library Standards Committee and [will be] reviewed for endorsement by the Kansas State Library Advisory Commission and the Kansas Library Association.
Kansas Library Association. Public Library Section. Standards Committee.
core  

ADP‐ribosylation: An emerging regulator of the epigenome

open access: yesMolecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho   +2 more
wiley   +1 more source

Adapt and advance: the Medical Library Association's journey through innovation and change

open access: yesJournal of the Medical Library Association
This article examines key inflection points of the last twenty-five years and the critical role of the board of directors in setting the direction of MLA.
Kevin Baliozian
doaj   +1 more source

Correction to “Satellite stories: capturing professional experiences of academic health sciences librarians working in delocalized health sciences programs” on page 80, 106(1) January. DOI: http://dx.doi.org/10.5195/jmla.2018.214

open access: yesJournal of the Medical Library Association, 2018
Corrects author photos in the hypertext markup language (HTML) version of “Satellite stories: capturing professional experiences of academic health sciences librarians working in delocalized health sciences programs” on page 80, 106(1) January. DOI: http:
Katherine G. Akers
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

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