Results 241 to 250 of about 812,040 (305)

A Mitochondria‐Specific Nanomedicine for Synergistic Chemo‐Photothermal Therapy and Immunogenic Activation Against Breast Cancer

Advanced Science, EarlyView.
Peptide dendrimer–based nanoplatform with mitochondria‐targeting capability was developed for synergistic chemo‐photothermal therapy. The system promotes efficient transcytosis, induces mitochondrial dysfunction, triggers immunogenic cell death (ICD), and enhance antitumor immunity by promoting dendritic cell maturation and T‐cell activation, resulting
Min Li, Jiangqi Feng, Junyang Zhuang, Qingguo Zhong, Yanda Li, Yanzhuo Lv, Shaoteng Huang, Xiangyu Huang, Mingbo Zhang, Xiaofeng Cai, Yuxin Wang, Wenping Chen, Zhenyu Duan, Zhou Chen, Kui Luo, Ning Li   +15 more
wiley   +1 more source

Evidence-Guided Diagnostic Reasoning for Pediatric Chest Radiology Based on Multimodal Large Language Models. [PDF]

J Imaging
Zhao Y, Wang Q, Wang Y, Zhao R, Feng R, Zhang X.   +5 more
europepmc   +1 more source

Integrating Human Intestinal Organoids into FDA'S New Approach Methodologies for Drug Discovery

Advanced Science, EarlyView.
Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra, Ibrahim M. Sayed, Souhrid Mukherjee, Honit Piplani, Aida Habtezion, Michael J. Rosen, Jospeh C. Wu   +6 more
wiley   +1 more source

Interpretable chronic obstructive pulmonary disease identification using chest X-ray radiomics: a multicenter study. [PDF]

Insights Imaging
Zhou Q, Zhai W, Zhou T, Wang Y, Zhou X, Lin X, Li J, Wu H, Dai Q, Ma Y, Xu F, Zhang H, Ge Y, Fan L.   +13 more
europepmc   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Real-World Analysis of Multidisciplinary Roles in the Management of Hepatocellular Carcinoma: The Mayo Clinic Experience. [PDF]

J Hepatocell Carcinoma
Islam FZ, De La Garza-Ramos C, Majeed U, Rutenberg M, Croome K, Yang L, Harnois D, Mathur AK, Roberts LR, Patel T, Lewandowski RJ, Toskich BB.   +11 more
europepmc   +1 more source

Bow hunter's syndrome secondary to lateral and posterior spondylosis: illustrative case. [PDF]

J Neurosurg Case Lessons
Zhu F, Wang H.
europepmc   +1 more source

Editorial: Emergency radiology: between unsolved problems and new challenges. [PDF]

Front Radiol
Di Grezia G, Scaglione M, Tamburrini S, Sica G.   +3 more
europepmc   +1 more source

Massive hemothorax following CT-guided lung biopsy: A rare iatrogenic complication managed conservatively. [PDF]

Trauma Case Rep
Rasuli B, Yazdi AF.
europepmc   +1 more source

Approval of AI-Based Medical Devices in China From 2020 to 2025: Retrospective Analysis.

JMIR Med Inform
Zhang L, Yan J.
europepmc   +1 more source