Results 101 to 110 of about 62,376 (291)

Privacy-preserving record linkage by a federated trusted third party (fTTP) – unlocking medical research potential in Germany

GMS Medizinische Informatik, Biometrie und Epidemiologie
Introduction: In the context of the COVID-19 pandemic, the urgent need for centralized research infrastructures became clear in Germany. Based thereon, large multicenter medical research projects, such as the Network of University Medicine (NUM) were ...
Hampf, Christopher, Bialke, Martin, Hund, Hauke, Fegeler, Christian, Lang, Stefan, Penndorf, Peter, Wöller, Nico, Moser, Frank-Michael, Blumentritt, Arne, Schuldt, Ronny, Seidel, Florian, Brunecker, Peter, Wettstein, Reto, Arnecke, Lukas, Hoffmann, Wolfgang   +14 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Advances in Privacy Preserving Record Linkage

, 2011
However, even though many solutions have been proposed towards addressing this problem, a new side effect rises regarding the privacy of the data which usually has to be protected during linkage.
Alexandros Karakasidis, Vassilios S. Verykios   +1 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Notifications of hospital events to outpatient clinicians using health information exchange: a post-implementation survey

Journal of Innovation in Health Informatics, 2013
Background The trend towards hospitalist medicine can lead to disjointed patient care. Outpatient clinicians may be unaware of patients’ encounters with a disparate healthcare system.
Richard Altman, Jason S Shapiro, Thomas Moore, Gilad J Kuperman   +3 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

A record linkage study of antidepressant medication use and weight change in Australian adults

Australian & New Zealand Journal of Psychiatry, 2015
Objective: Antidepressant use is widespread. While weight gain is a commonly reported side-effect of antidepressant use and has the potential to affect population health, there is little large-scale population-based evidence on the issue, particularly for long-term use (⩾12 months).
Paige, Ellie, Korda, Rosemary, Kemp-Casey, Anna, Dobbins, Timothy, Banks, Emily, Rodgers, Bryan   +5 more
openaire   +3 more sources

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Probabilistic Record Linkage System for Maternal Mortality [PDF]

, 2010
Computerized record linkage is increasing used in health information systems. Medical record linkage expresses the concept of collecting health care records into commutative personal file, starting with birth and ending with death.
Htike, Thin Thin, Wai, Saw Yu Yu
core  

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source