Results 191 to 200 of about 7,033,572 (264)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Framework development of the social impact of medical research utilization: Fuzzy Delphi approach. [PDF]

Health Res Policy Syst
Nazeri N, Hosseini Golkar M, Noruzi A, Shabani A.   +3 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Institution-wide strategies for research integrity training: experience from the Kenya Medical Research Institute: a descriptive case study. [PDF]

BMC Res Notes
Kebenei E, Olungae D, Sang GN, Nguya J, Chepngetich J, Makobu K, Katindi M, Mwangi MJ, Muhudhia SO, Soi VC, Bukusi EA, Bulimo WD.   +11 more
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Reporting guideline for the use of Generative Artificial intelligence tools in MEdical Research: the GAMER Statement. [PDF]

BMJ Evid Based Med
Luo X, Luo X, Tham YC, Giuffrè M, Ranisch R, Daher M, Lam K, Eriksen AV, Hsu CW, Ozaki A, Moraes FY, Khanna S, Su KP, Begagić E, Bian Z, Chen Y, Estill J, GAMER Working Group.   +17 more
europepmc   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Undergraduate medical research in the West Bank, Palestine: a cross-sectional analysis of student knowledge, attitudes, barriers, and engagement across five universities. [PDF]

Front Med (Lausanne)
Zrineh A, Akwan R, Darawsheh R, Qawasmeh H, Zahdeh M, Sarrees YA, Shakhshir A, Awesat B, Mustafa W, Ishnawer I, Karmi H, Alwawi A.   +11 more
europepmc   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source