Results 41 to 50 of about 3,408,002 (265)

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Association Between Individualized Education for Kidney Replacement Therapy Modality Selection and Peritoneal Dialysis Initiation: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito, Ryuichi Yoshimura, Takaki Yamauchi, Yuta Funakoshi, Hirotaka Sonoda, Seiji Kobayashi, Hiroyuki Terawaki, Takafumi Ito   +7 more
wiley   +1 more source

Beta-cell-specific C3 deficiency exacerbates metabolic dysregulation and insulin resistance in obesity

Molecular Metabolism
Background: C3 is highly expressed in human and rodent pancreatic islets, which secrete insulin to regulate blood glucose homeostasis. We have previously shown that cytosolic C3 protects pancreatic beta-cells from stress, by allowing cytoprotective ...
Ben C. King, Lucie Colineau, Julia Slaby, Olga Kolodziej, Vaishnavi Dandavate, Robin Olsson, Malin Fex, Anna M. Blom   +7 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

A Recent Insight on Prevalence of atopic diseases in children with type 1 diabetes

Journal of Medicine in Scientific Research
Background Type 1 diabetes mellitus (T1DM) and atopic diseases are both prevalent immunemediated conditions in children. Although traditionally viewed as immunologically opposing disorders—T1DM being Th1-mediated and atopy Th2-mediated—recent studies ...
Randa Mohamed Darwish, Ayat Ibrahim Ghanem   +1 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

THE CHANGES OF CHOLINERGIC NEUROTRANSMITTER IN DIFFERENT PARTS OF THE BRAIN UNDER ELECTROACUPUNCTURE ANALGESIA IN RABBITS

针刺研究, 1980
For the purpose of elucidating the role of the cholinergic nervous system in the process of acupuncture analgesia,the content of acetylcholine(ACh)and the activity of acetylcholinesterase(ACHE)in different parts of the rabbit brain were estimated under ...
Huang Xingya Lu Chunhui Sun Huiqiao Department of Physiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences.   +2 more
doaj  

Efficacy and Safety of Different Treatment Strategies in Pediatric Fecal Incontinence: A Systematic Review

Journal of Medicine in Scientific Research
Background Fecal incontinence (FI) in children is a challenging condition with significant impacts on quality of life (QoL). Multiple therapeutic approaches, including neuromodulation techniques such as sacral nerve stimulation (SNS), biofeedback therapy,
Seham M. Abd El-Moghny, Wessam A. Al-kholy, Mohamed I. Elsepaee, Ahmed M. Elgamal, Rabab S. Mohamed   +4 more
doaj   +1 more source